Mastgell

Mastgell
Enghraifft o'r canlynol	math o gell
Math	cell hemal gwahaniaethol
Label brodorol	mastocytus
Enw brodorol	mastocytus
	Ffeiliau perthnasol ar Gomin Wicimedia

Math o gell gwyn y gwaed yw Mastgell. Yn benodol, mae'n fath o granulocyte sy'n tarddu o'r gell fonyn myeloid sy'n rhan o'r systemau imiwnyddol a niwroimiwnyddol ac yn cynnwys nifer o ronynnau sy'n gyfoethog o histamin a heparin. Er eu bod yn cael eu hadnabod orau am eu rhan mewn alergedd a anaphylaxis, mae gan fasgelloedd ran bwysig hefyd yn gwarchod y corff, yn cydrannu at wella clwyfau, angiogenesis, goddefiad imiwnyddol, amddiffyniad yn erbyn pathogenau, a ffwythiant gwahanfur gwaed ac ymenydd.^[1]

Mae'r mastgell yn debyg iawn o ran ei wedd a'i waith i'r basoffil, math arall o gell gwyn y gwaed. Er y credid ar un adeg mai basoffilau oedd yn preswylio mewn meinwe oedd y mastgelloedd, mae wedi'i ddangos bod y ddau gell yn datblygu o wahanol linachau hematopoietig ac na fedrant felly fod yr un celloedd.^[2]

↑ "Mast cell function: a new vision of an old cell". J. Histochem. Cytochem. 62 (10): 698–738. 2014. doi:10.1369/0022155414545334. PMC 4230976. PMID 25062998. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4230976. "Mast cells can recognize pathogens through different mechanisms including direct binding of pathogens or their components to PAMP receptors on the mast cell surface, binding of antibody or complement-coated bacteria to complement or immunoglobulin receptors, or recognition of endogenous peptides produced by infected or injured cells (Hofmann and Abraham 2009). The pattern of expression of these receptors varies considerably among different mast cell subtypes. TLRs (1–7 and 9), NLRs, RLRs, and receptors for complement are accountable for most mast cell innate responses"
↑ "Distinguishing mast cell and granulocyte differentiation at the single-cell level". Cell Stem Cell 6: 361–8. 2010. doi:10.1016/j.stem.2010.02.013. PMC 2852254. PMID 20362540. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2852254.

[Mast_cell_function-1] "Mast cell function: a new vision of an old cell". J. Histochem. Cytochem. 62 (10): 698–738. 2014. doi:10.1369/0022155414545334. PMC 4230976. PMID 25062998. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4230976. "Mast cells can recognize pathogens through different mechanisms including direct binding of pathogens or their components to PAMP receptors on the mast cell surface, binding of antibody or complement-coated bacteria to complement or immunoglobulin receptors, or recognition of endogenous peptides produced by infected or injured cells (Hofmann and Abraham 2009). The pattern of expression of these receptors varies considerably among different mast cell subtypes. TLRs (1–7 and 9), NLRs, RLRs, and receptors for complement are accountable for most mast cell innate responses"

[2] "Distinguishing mast cell and granulocyte differentiation at the single-cell level". Cell Stem Cell 6: 361–8. 2010. doi:10.1016/j.stem.2010.02.013. PMC 2852254. PMID 20362540. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2852254.

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