Sinukleinopatija

Sinukleinopatija
Sinukleinopatija
Sinonim	α-Sinukleinopatije
	Pozitivno bojenje Levijevih tela α-sinukleinom kod pacijenta sa Parkinsonovom bolešću.
Specijalnosti	neurologija
	[uredi na Vikipodacima]

Sinukleinopatije (takođe zvane α-sinukleinopatije) su neurodegenerativne bolesti koje karakteriše abnormalna akumulacija agregata alfa-sinuklein proteina u neuronima, nervnim vlaknima ili glijalnim ćelijama.^[1] Postoje tri glavna tipa sinukleinopatije: Parkinsonova bolest (PD), demencija sa Levijevim telima (DLB) i multipla sistemska atrofija (MSA).^[1] Drugi retki poremećaji, kao što su različite neuroaksonalne distrofije, takođe imaju α-sinukleinske patologije.^[2] Pored toga, studije autopsija su pokazale da oko 6% sporadične Alchajmerove bolesti pokazuje α-sinuklein pozitivnu Levijevu patologiju i da je podklasifikovana kao Alchajmerova bolest sa amigdalarnim ograničenim Levijevim telima (AD/ALB).^[3]^[4]^[5]^[6]^[7]

^ ^а ^б McCann H, Stevens CH, Cartwright H, Halliday GM (2014). „Α-Synucleinopathy phenotypes”. Parkinsonism & Related Disorders. 20 Suppl 1: S62—S67. PMID 24262191. doi:10.1016/S1353-8020(13)70017-8. hdl:1959.4/53593 .
^ Goedert M, Jakes R, Spillantini MG (2017). „The Synucleinopathies: Twenty Years On”. J Parkinsons Dis. 7 (s1): S53—S71. PMC 5345650 . PMID 28282814. doi:10.3233/JPD-179005.
^ Arai, Yasushi; Yamazaki, Mineo; Mori, Osamu; Muramatsu, Hiromi; Asano, Goro; Katayama, Yasuo (јануар 2001). „α-Synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation”. Brain Research. 888 (2): 287—296. PMID 11150486. S2CID 3044534. doi:10.1016/S0006-8993(00)03082-1.
^ Nelson, Peter T; Abner, Erin L; Patel, Ela; Anderson, Sonya; Wilcock, Donna M; Kryscio, Richard J; Van Eldik, Linda J; Jicha, Gregory A; Gal, Zsombor; Nelson, Ruth S; Nelson, Bela G; Gal, Jozsef; Azam, Md. Tofial; Fardo, David W; Cykowski, Matthew D (1. 1. 2018). „The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases”. Journal of Neuropathology & Experimental Neurology. 77 (1): 2—20. PMC 5901077 . PMID 29186501. doi:10.1093/jnen/nlx099.
^ Hamilton, Ronald L. (5. 4. 2006). „Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α-Synuclein Immunohistochemistry”. Brain Pathology. 10 (3): 378—384. PMID 10885656. doi:10.1111/j.1750-3639.2000.tb00269.x.
^ Toledo, Jon B.; Gopal, Pallavi; Raible, Kevin; Irwin, David J.; Brettschneider, Johannes; Sedor, Samantha; Waits, Kayla; Boluda, Susana; Grossman, Murray; Van Deerlin, Vivianna M.; Lee, Edward B.; Arnold, Steven E.; Duda, John E.; Hurtig, Howard; Lee, Virginia M.-Y.; Adler, Charles H.; Beach, Thomas G.; Trojanowski, John Q. (март 2016). „Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology”. Acta Neuropathologica. 131 (3): 393—409. PMC 4754135 . PMID 26721587. doi:10.1007/s00401-015-1526-9.
^ Uchikado, Hirotake; Lin, Wen-Lang; DeLucia, Michael W.; Dickson, Dennis W. (јул 2006). „Alzheimer Disease With Amygdala Lewy Bodies: A Distinct Form of α-Synucleinopathy”. Journal of Neuropathology and Experimental Neurology. 65 (7): 685—697. PMC 5706655 . PMID 16825955. doi:10.1097/01.jnen.0000225908.90052.07.

[phenotypes-1] а ^б McCann H, Stevens CH, Cartwright H, Halliday GM (2014). „Α-Synucleinopathy phenotypes”. Parkinsonism & Related Disorders. 20 Suppl 1: S62—S67. PMID 24262191. doi:10.1016/S1353-8020(13)70017-8. hdl:1959.4/53593 .

[Goedert2017-2] Goedert M, Jakes R, Spillantini MG (2017). „The Synucleinopathies: Twenty Years On”. J Parkinsons Dis. 7 (s1): S53—S71. PMC 5345650 . PMID 28282814. doi:10.3233/JPD-179005.

[3] Arai, Yasushi; Yamazaki, Mineo; Mori, Osamu; Muramatsu, Hiromi; Asano, Goro; Katayama, Yasuo (јануар 2001). „α-Synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation”. Brain Research. 888 (2): 287—296. PMID 11150486. S2CID 3044534. doi:10.1016/S0006-8993(00)03082-1.

[4] Nelson, Peter T; Abner, Erin L; Patel, Ela; Anderson, Sonya; Wilcock, Donna M; Kryscio, Richard J; Van Eldik, Linda J; Jicha, Gregory A; Gal, Zsombor; Nelson, Ruth S; Nelson, Bela G; Gal, Jozsef; Azam, Md. Tofial; Fardo, David W; Cykowski, Matthew D (1. 1. 2018). „The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases”. Journal of Neuropathology & Experimental Neurology. 77 (1): 2—20. PMC 5901077 . PMID 29186501. doi:10.1093/jnen/nlx099.

[5] Hamilton, Ronald L. (5. 4. 2006). „Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α-Synuclein Immunohistochemistry”. Brain Pathology. 10 (3): 378—384. PMID 10885656. doi:10.1111/j.1750-3639.2000.tb00269.x.

[6] Toledo, Jon B.; Gopal, Pallavi; Raible, Kevin; Irwin, David J.; Brettschneider, Johannes; Sedor, Samantha; Waits, Kayla; Boluda, Susana; Grossman, Murray; Van Deerlin, Vivianna M.; Lee, Edward B.; Arnold, Steven E.; Duda, John E.; Hurtig, Howard; Lee, Virginia M.-Y.; Adler, Charles H.; Beach, Thomas G.; Trojanowski, John Q. (март 2016). „Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology”. Acta Neuropathologica. 131 (3): 393—409. PMC 4754135 . PMID 26721587. doi:10.1007/s00401-015-1526-9.

[7] Uchikado, Hirotake; Lin, Wen-Lang; DeLucia, Michael W.; Dickson, Dennis W. (јул 2006). „Alzheimer Disease With Amygdala Lewy Bodies: A Distinct Form of α-Synucleinopathy”. Journal of Neuropathology and Experimental Neurology. 65 (7): 685—697. PMC 5706655 . PMID 16825955. doi:10.1097/01.jnen.0000225908.90052.07.

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