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Troponin

Troponin
Purposeto detect myocardial damage
Ribbon representation of the human cardiac troponin core complex (52 kDa core) in the calcium-saturated form. Blue = troponin C; green = troponin I; magenta = troponin T.[1]

Troponin, or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that are integral to muscle contraction[2] in skeletal muscle and cardiac muscle, but not smooth muscle. Measurements of cardiac-specific troponins I and T are extensively used as diagnostic and prognostic indicators in the management of myocarditis, myocardial infarction and acute coronary syndrome.[3] Blood troponin levels may be used as a diagnostic marker for stroke or other myocardial injury that is ongoing, although the sensitivity of this measurement is low.[4][5][6][7][8]

  1. ^ PDB: 1J1E​; Takeda S, Yamashita A, Maeda K, Maeda Y (2003). "Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form". Nature. 424 (6944): 35–41. Bibcode:2003Natur.424...35T. doi:10.1038/nature01780. PMID 12840750. S2CID 2174019.; rendered with PyMOL
  2. ^ "troponin" at Dorland's Medical Dictionary
  3. ^ "Troponin - Understand the Test & Your Results". labtestsonline.org. Retrieved 2019-04-18.
  4. ^ Strandberg, Love S.; Roos, Andreas; Holzmann, Martin J. (2021-01-01). "Stable high-sensitivity cardiac troponin T levels and the association with frailty and prognosis in patients with chest pain". American Journal of Medicine Open. 1–6: 100001. doi:10.1016/j.ajmo.2021.100001. ISSN 2667-0364. PMC 11256254. S2CID 244507759.
  5. ^ A Roos, U Sartipy, R Ljung, MJ. Holzmann Relation of chronic myocardial injury and Non-ST-Segment elevation myocardial infarction to mortality Am J Cardiol, 122 (2018), pp. 1989-1995,
  6. ^ A Roos, N Bandstein, M Lundbäck, O Hammarsten, R Ljung, MJ. Holzmann Stable high-sensitivity cardiac troponin T levels and outcomes in patients with chest pain J Am Coll Cardiol, 70 (18) (2017), pp. 2226-2236,
  7. ^ Thygesen, Kristian; Alpert, Joseph S.; Jaffe, Allan S.; Chaitman, Bernard R.; Bax, Jeroen J.; Morrow, David A.; White, Harvey D. (2018-10-30). "Fourth Universal Definition of Myocardial Infarction (2018)". Journal of the American College of Cardiology. 72 (18): 2231–2264. doi:10.1016/j.jacc.2018.08.1038. hdl:10044/1/73052. ISSN 0735-1097. PMID 30153967. S2CID 52110825.
  8. ^ Kerr, Gillian; Ray, Gautamananda; Wu, Olivia; Stott, David J.; Langhorne, Peter (2009). "Elevated troponin after a stroke: a systematic review". Cerebrovascular Diseases. 28 (3): 220–226. doi:10.1159/000226773. ISSN 1421-9786. PMID 19571535.

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