Somatostatin

SST
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2MI1
Identifikatori
Aliasi	SST
Vanjski ID-jevi	OMIM: 182450 MGI: 98326 HomoloGene: 819 GeneCards: SST
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	187,670,394 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	23,709,708 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• hormone activity;
Ćelijska komponenta	• extracellular region; • soma; • Vanćelijsko;
Biološki proces	• negative regulation of cell population proliferation; • hormone-mediated apoptotic signaling pathway; • hyperosmotic response; • chemical synaptic transmission; • regulation of cell migration; • response to heat; • response to nutrient; • response to acidic pH; • response to steroid hormone; • G protein-coupled receptor signaling pathway; • response to amino acid; • cell-cell signaling; • response to organonitrogen compound; • varenje; • cell surface receptor signaling pathway; • regulation of signaling receptor activity;
	Izvori:Amigo / QuickGO
Ortolozi
	6750
	20604
	ENSG00000157005
	ENSMUSG00000004366
	P61278
	P60041
	NM_001048
	NM_009215
	NP_001039
	NP_033241
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Somatostatin, poznat i kao hormon inhibicije rasta (GHIH) ili nekoliko drugih imena, je peptidni hormon koji regulira endokrini sistem i izazina neurotransmisiju i ćelijsku proliferaciju preko interakcije sa G-protein spregnutim receptorima somatostatina i inhibicije otpuštanja brojnih sekundarnih hormona. Somatostatin koći djelovanje insulina i lučenje glukagona.^[5]

Somatostatin ima dva aktivna oblika, nastala alternativnim cijepanjem jednog preproteina: jednog koji se sastoji od 14 aminokiselina (prikazan u infoboksu desno) i drugog koji se sastoji od 28 aminokiselina.^[6]^[7]

Među kičmenjacima, postoji šest različitih somatostatinskig gena, označenih sa SS1, SS2, SS3, SS4, SS5 i SS6.^[8] Riba zebra ima svih šest.^[8] Šest različitih gena, zajedno s pet različitih receptora somatostatina, omogućavaju somatostatinu veliki raspon funkcija.^[9] Ljudi imaju samo somatostatinski gen SST.^[10]^[11]^[12]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157005 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004366 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "somatostatin". Encyclopædia Britannica. Encyclopædia Britannica Online. Encyclopædia Britannica Inc., 2016. Web. 04 mag. 2016 <http://www.britannica.com/science/somatostatin>.
^ Costoff A. "Sect. 5, Ch. 4: Structure, Synthesis, and Secretion of Somatostatin". Endocrinology: The Endocrine Pancreas. Medical College of Georgia. str. 16. Arhivirano s originala, 5. 4. 2008. Pristupljeno 19. 2. 2008.
^ "somatostatin preproprotein [Homo sapiens]". NCBI Reference Sequence. National Center for Biotechnology Information Support Center (NCBI).
^ ^a ^b Liu Y, Lu D, Zhang Y, Li S, Liu X, Lin H (septembar 2010). "The evolution of somatostatin in vertebrates". Gene. 463 (1–2): 21–8. doi:10.1016/j.gene.2010.04.016. PMID 20472043.
^ Gahete MD, Cordoba-Chacón J, Duran-Prado M, Malagón MM, Martinez-Fuentes AJ, Gracia-Navarro F, Luque RM, Castaño JP (juli 2010). "Somatostatin and its receptors from fish to mammals". Annals of the New York Academy of Sciences. 1200: 43–52. doi:10.1111/j.1749-6632.2010.05511.x. PMID 20633132.
^ "Entrez Gene: Somatostatin".
^ Shen LP, Pictet RL, Rutter WJ (august 1982). "Human somatostatin I: sequence of the cDNA". Proceedings of the National Academy of Sciences of the United States of America. 79 (15): 4575–9. doi:10.1073/pnas.79.15.4575. PMC 346717. PMID 6126875.
^ Shen LP, Rutter WJ (april 1984). "Sequence of the human somatostatin I gene". Science. 224 (4645): 168–71. doi:10.1126/science.6142531. PMID 6142531.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157005 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004366 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "somatostatin". Encyclopædia Britannica. Encyclopædia Britannica Online. Encyclopædia Britannica Inc., 2016. Web. 04 mag. 2016 <http://www.britannica.com/science/somatostatin>.

[GP5416-6] Costoff A. "Sect. 5, Ch. 4: Structure, Synthesis, and Secretion of Somatostatin". Endocrinology: The Endocrine Pancreas. Medical College of Georgia. str. 16. Arhivirano s originala, 5. 4. 2008. Pristupljeno 19. 2. 2008.

[7] "somatostatin preproprotein [Homo sapiens]". NCBI Reference Sequence. National Center for Biotechnology Information Support Center (NCBI).

[Liu-8] Liu Y, Lu D, Zhang Y, Li S, Liu X, Lin H (septembar 2010). "The evolution of somatostatin in vertebrates". Gene. 463 (1–2): 21–8. doi:10.1016/j.gene.2010.04.016. PMID 20472043.

[Gahete-9] Gahete MD, Cordoba-Chacón J, Duran-Prado M, Malagón MM, Martinez-Fuentes AJ, Gracia-Navarro F, Luque RM, Castaño JP (juli 2010). "Somatostatin and its receptors from fish to mammals". Annals of the New York Academy of Sciences. 1200: 43–52. doi:10.1111/j.1749-6632.2010.05511.x. PMID 20633132.

[entrez-10] "Entrez Gene: Somatostatin".

[pmid6126875-11] Shen LP, Pictet RL, Rutter WJ (august 1982). "Human somatostatin I: sequence of the cDNA". Proceedings of the National Academy of Sciences of the United States of America. 79 (15): 4575–9. doi:10.1073/pnas.79.15.4575. PMC 346717. PMID 6126875.

[pmid6142531-12] Shen LP, Rutter WJ (april 1984). "Sequence of the human somatostatin I gene". Science. 224 (4645): 168–71. doi:10.1126/science.6142531. PMID 6142531.

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