Back 2-بوتوكسي إيثانول Arabic ۲-بوتوکسیاتانول AZB 2-butoxyethanol Czech Ethylenglycolmonobutylether German ۲-بوتوکسیاتانول Persian 2-butoksietanoli Finnish 2-Butoxyéthanol French 2-ब्यूटॉक्सीइथेनाल Hindi 2-ブトキシエタノール Japanese 2-butoxyethanol Dutch
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| Names | |
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| Preferred IUPAC name
2-Butoxyethanol | |
| Other names
2-Butoxyethanol
Butyl cellosolve Butyl glycol Butyl monoether glycol EGBE (ethylene glycol monobutyl ether) Dowanol EB Eastman EB solvent 2-BE EGMBE Butyl oxitol Ektasolve EB Jeffersol EB | |
| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.003.550 |
| EC Number |
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PubChem CID
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| RTECS number |
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| UNII | |
| UN number | 1993, 2810, 2369 |
CompTox Dashboard (EPA)
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| Properties | |
| C6H14O2 | |
| Molar mass | 118.176 g·mol−1 |
| Appearance | Clear, colorless liquid |
| Density | 0.90 g/cm3, liquid |
| Melting point | −77 °C (−107 °F; 196 K) |
| Boiling point | 171 °C (340 °F; 444 K) |
| Miscible (and in most organic solvents) | |
| Vapor pressure | 0.8 mmHg[1] |
| Acidity (pKa) | High pKa for −OH group |
Refractive index (nD)
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1.4198 (20 °C)[2] |
| Viscosity | 2.9 cP at 25 °C (77 °F) |
| 2.08 D[2] | |
| Hazards | |
| GHS labelling: | |
  
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| Danger | |
| H227, H302, H311, H315, H319, H330, H336, H361, H370, H372 | |
| P201, P202, P210, P260, P261, P264, P270, P271, P280, P281, P284, P301+P312, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501 | |
| NFPA 704 (fire diamond) | |
| Flash point | 67 °C (153 °F; 340 K) |
| 245 °C (473 °F; 518 K) | |
| Explosive limits | 1.1–12.7%[1] |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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1230 mg/kg (mouse, oral) 470 mg/kg (rat, oral) 300 mg/kg (rabbit, oral) 1200 mg/kg (guinea pig, oral) 1480 mg/kg (rat, oral)[3] |
LC50 (median concentration)
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450 ppm (rat, 4 hr) 700 ppm (mouse, 7 hr)[3] |
| NIOSH (US health exposure limits): | |
PEL (Permissible)
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TWA 50 ppm (240 mg/m3) [skin][1] |
REL (Recommended)
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TWA 5 ppm (24 mg/m3) [skin][1] |
IDLH (Immediate danger)
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700 ppm[1] |
| Safety data sheet (SDS) | [1] |
| Related compounds | |
Related ethers
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2-Methoxyethanol 2-Ethoxyethanol |
Related compounds
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Ethylene glycol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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2-Butoxyethanol is an organic compound with the chemical formula BuOC2H4OH (Bu = CH3CH2CH2CH2). This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol. As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. It is a known respiratory irritant[4] and can be acutely toxic, but animal studies did not find it to be mutagenic, and no studies suggest it is a human carcinogen.[5] A study of 13 classroom air contaminants conducted in Portugal reported a statistically significant association with increased rates of nasal obstruction and a positive association below the level of statistical significance with a higher risk of obese asthma and increased body mass index.[6]
- ^ a b c d e NIOSH Pocket Guide to Chemical Hazards. "#0070". National Institute for Occupational Safety and Health (NIOSH).
- ^ a b William M. Haynes, ed. (2016). CRC handbook of chemistry and physics : a ready-reference book of chemical and physical data (97th ed.). Boca Raton, Florida: CRC Press. ISBN 978-1-4987-5428-6. OCLC 930681942.
- ^ a b "2-Butoxyethanol". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
- ^ "Toxnet Has Moved". www.nlm.nih.gov. Retrieved 2020-01-24.
- ^ "Public Health Statement for 2-Butoxyethanol and 2-Butoxyethanol Acetate". Agency for Toxic Substances and Disease Registry, Center for Disease Control. August 1998. Retrieved 16 February 2020.
- ^ Paciência, Inês; Cavaleiro Rufo, João; Silva, Diana; Martins, Carla; Mendes, Francisca; Farraia, Mariana; Delgado, Luís; De Oliveira Fernandes, Eduardo; Padrão, Patrícia; Moreira, Pedro; Severo, Milton; Barros, Henrique; Moreira, André (2019). "Exposure to indoor endocrine-disrupting chemicals and childhood asthma and obesity". Allergy. 74 (7): 1277–1291. doi:10.1111/all.13740. PMID 30740706. S2CID 73443692.