The forty-second edition of the Caribbean Series (Serie del Caribe) was held from February 2 through February 8 of 2000 with the champion baseball teams of the Dominican Republic, Águilas Cibaeñas; Mexico, Mayos de Navojoa; Puerto Rico, Cangrejeros de Santurce, and Venezuela, Águilas del Zulia. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Estadio Quisqueya in Santo Domingo, Dominican Republic.