The 2010 F4 Eurocup 1.6 was the eighteenth season of the series for 1600cc Formula Renault machinery, and the only season run under the guise of F4 Eurocup 1.6. The series began on 17 April at Motorland Aragon and ended on 10 October at Circuit de Catalunya, after seven rounds and fourteen races.
Stoffel Vandoorne clinched the championship with a meeting to spare, winning six races en route to a 36-point championship winning margin over Norman Nato, with Mathieu Jaminet edging out Paul-Loup Chatin for third place overall. Franck Matelli finished fifth; the only other driver to win a race over the season.
It was the final season run under the "F4 Eurocup 1.6" name, as the series was renamed the "French F4 Championship" for 2011.