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The 2022 Formula Regional European Championship by Alpine was a multi-event, Formula Regional open-wheel single seater motor racing championship held across Europe. The championship featured a mix of professional and amateur drivers, competing in Formula Regional cars that conform to the FIA Formula Regional regulations for the championship. This was the fourth season of the championship and the second after a merger with Formula Renault Eurocup which resulted to the change of the engine supplier to Alpine. The season commenced on 22 April at Autodromo Nazionale Monza and concluded on 23 October at Mugello Circuit, after ten rounds.
Prema Racing won their third teams' championship at Barcelona, with two races to spare. Their driver Dino Beganovic won the drivers' championship, with one race to spare. Leonardo Fornaroli, driving for Trident, won the rookie title.