Battle of Edessa: With a large army, said to number 70,000 men, Valerian attempts to drive the Persians back from Edessa. The Roman army is surrounded and most of its troops are killed or captured. Valerian is taken prisoner for the remainder of his life.
King Shapur I sends Valerian to Bishapur and uses the captured Roman army for engineering plans. They construct the Band-e Kaisar ("Bridge of Valerian").
Gallienus establishes himself at Mediolanum (modern Milan); he reorganizes the army, supported by elite cavalry, and dispatches troops to the Rhine frontier.
Postumus executes Saloninus and his adviser Silvanus after breaching the walls of Cologne. He is recognized as emperor and establishes his capital at Trier.
Emperor Cao Mao of Former Wei state attempts to lead a coup against the powerful regent Sima Zhao, but he himself is killed before it comes to a confrontation.
June 2 – Cao Mao is killed in a coup d'état against Sima Zhao. The 14-year-old Cao Huan becomes ruler of Former Wei, but the Sima clan controls the state.
Pope Dionysius convenes a synod at Rome to demand an explanation from bishop Dionysius of Alexandria, who has been charged with separating the members of the Trinity as three distinct deities.
Emperor Gallienus tries twice to crush the usurper Postumus, but on the first occasion Aureolus, commander of the elite cavalry, carelessly lets him escape. The second time, Gallienus sustains an arrow wound and has to break off his siege of a Gallic town where Postumus has holed up. He makes no other serious attempt to overcome his rival, instead devoting his attention to the political and military problems in the Danube and eastern parts of the Roman Empire.
Postumus makes no move to march on Rome and claim his territory south of Gaul.
Gallienus gives the order to fortify Milan and Verona.
Gallienus repels the invasion of the Goths in the Balkans.
A general of Gallienus' army, Victorinus, defects to Postumus.
Sima Zhao, who had been the regent and de facto primary authority of the state of Cao Wei for little over 10 years by this point, passes away, leaving his authority to his eldest son, Sima Yan, who will go on to disestablish the state of Cao Wei in February 266, founding the Jin dynasty.
King Odaenathus of Palmyra invades Persia to conquer the capital, Ctesiphon, and twice comes as far as the walls of the Persian capital, but fails to take it.[3][4][5] After his victories in the East, he pronounces himself with the title "king of kings".
A powerful tropical volcanic eruption around this year brings a below-average flood of the Nile next year.[6]
February 4 – Sima Yan, regent of the Chinese state of Cao Wei, forces the last Cao Wei emperor Cao Huan to abdicate in his favour. The Cao Wei state's existence comes to an end. Sima Yan establishes the Jin Dynasty, and becomes its first emperor on 8 February, and is historically known as "Wu of Jin". He establishes his capital at Luoyang, and gives his male relatives independent military commands throughout his empire.
The Heruli invade the Black Sea coast; they unsuccessfully attack Byzantium and Cyzicus. The Roman fleet defeats the Herulian fleet (500 ships) but allows them to escape into the Aegean Sea, where they raid the islands of Lemnos and Skyros.
The Goths sack several cities of southern Greece including Athens, Corinth, Argos and Sparta. After the Sack of Athens, an Athenian militia force (2,000 men), under the historian Dexippus, pushes the invaders to the north where they are intercepted by the Roman army under emperor Gallienus. He wins an important victory near the Nestos River, on the boundary between Macedonia and Thrace.
Aureolus, charged with defending Italy, defeats Victorinus (co-emperor of Gaul), is proclaimed emperor by his troops, and begins his march on Rome.
King Septimius Odaenathus of Palmyra makes plans for a campaign in Cappadocia against the Goths. He is assassinated, along with his eldest son, most probably by his nephew due to a previous altercation between him and Odaenathus.[7] His wife Zenobia succeeds him, and rules Vaballathus (the Palmyrene Empire) with her young son.
Marcus Aurelius Claudius, who may have murdered Gallienus, becomes the new emperor of Rome and will reign as Claudius II.
Claudius II asks the Senate to spare the lives of Gallienus's family and political supporters. Emperor Gallienus is deified and buried in a family tomb on the Appian Way.
Second Gothic invasion: The Goths and other German tribes attack Bosphorean towns on the coast of the Black Sea. Some 2,000 ships and 320,000 men from the Danube enter Roman territory. Emperor Claudius II defeats the invaders and receives the title Gothicus for his triumph. Many of the prisoners will serve in the Roman legions and settle in vacant lands in the Danubian provinces.[10]
Claudius II travels to Sirmium and prepares a war against the Vandals, who raid Pannonia.