Adenosine A2A receptor

ADORA2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YDO, 2YDV, 3EML, 3PWH, 3QAK, 3REY, 3RFM, 3UZA, 3UZC, 3VG9, 3VGA, 4EIY, 4UG2, 4UHR, 5IU4, 5IU7, 5IUA, 5IU8, 5IUB
Identifiers
Aliases	ADORA2A, adenosine A2a receptor, A2aR, ADORA2, RDC8
External IDs	OMIM: 102776; MGI: 99402; HomoloGene: 20166; GeneCards: ADORA2A; OMA:ADORA2A - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	24,442,357 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,170,618 bp
RNA expression pattern
	Top expressed in
	putamen; ; caudate nucleus; ; nucleus accumbens; ; blood; ; bone marrow; ; right lobe of liver; ; lymph node; ; apex of heart; ; granulocyte; ; bone marrow cells;
	Top expressed in
	olfactory tubercle; ; superior frontal gyrus; ; perirhinal cortex; ; Ileal epithelium; ; globus pallidus; ; nucleus accumbens; ; entorhinal cortex; ; embryo; ; thymus; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled adenosine receptor activity; G protein-coupled receptor activity; signal transducer activity; protein binding; identical protein binding; enzyme binding; alpha-actinin binding; type 5 metabotropic glutamate receptor binding; protein heterodimerization activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intermediate filament; endomembrane system; postsynaptic density; axon; dendrite; axolemma; asymmetric synapse; presynaptic membrane; soma; postsynaptic membrane; presynaptic active zone; integral component of postsynaptic membrane; integral component of presynaptic membrane; glutamatergic synapse; Golgi membrane;
Biological process	cAMP biosynthetic process; G protein-coupled adenosine receptor signaling pathway; sensory perception; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell-cell signaling; blood coagulation; blood circulation; cellular defense response; central nervous system development; phagocytosis; inflammatory response; signal transduction; apoptotic process; synaptic transmission, dopaminergic; response to amphetamine; regulation of transcription, DNA-templated; negative regulation of protein kinase activity; protein kinase C-activating G protein-coupled receptor signaling pathway; synaptic transmission, cholinergic; locomotory behavior; negative regulation of cell population proliferation; positive regulation of glutamate secretion; positive regulation of acetylcholine secretion, neurotransmission; regulation of norepinephrine secretion; response to caffeine; positive regulation of synaptic transmission, GABAergic; synaptic transmission, glutamatergic; positive regulation of urine volume; positive regulation of renal sodium excretion; negative regulation of locomotion; vasodilation; eating behavior; negative regulation of vascular permeability; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to alkaloid; negative regulation of neuron apoptotic process; positive regulation of circadian sleep/wake cycle, sleep; negative regulation of alpha-beta T cell activation; astrocyte activation; neuron projection morphogenesis; positive regulation of protein secretion; negative regulation of inflammatory response; regulation of mitochondrial membrane potential; membrane depolarization; regulation of calcium ion transport; positive regulation of synaptic transmission, glutamatergic; excitatory postsynaptic potential; inhibitory postsynaptic potential; prepulse inhibition; positive regulation of apoptotic signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of long-term synaptic potentiation; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	135
	11540
	ENSG00000128271
	ENSMUSG00000020178
	P29274
	Q60613
	NM_000675; NM_001278497; NM_001278498; NM_001278499; NM_001278500
	NM_009630; NM_001331095; NM_001331096
	NP_000666; NP_001265426; NP_001265427; NP_001265428; NP_001265429
	NP_001318024; NP_001318025; NP_033760
	Wikidata
View/Edit Human	View/Edit Mouse

The adenosine A_2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128271 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020178 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, et al. (May 1989). "Selective amplification and cloning of four new members of the G protein-coupled receptor family". Science. 244 (4904): 569–72. Bibcode:1989Sci...244..569L. doi:10.1126/science.2541503. PMID 2541503.
^ Libert F, Passage E, Parmentier M, Simons MJ, Vassart G, Mattei MG (September 1991). "Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor". Genomics. 11 (1): 225–7. doi:10.1016/0888-7543(91)90125-X. PMID 1662665.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128271 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020178 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2541503-5] Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, et al. (May 1989). "Selective amplification and cloning of four new members of the G protein-coupled receptor family". Science. 244 (4904): 569–72. Bibcode:1989Sci...244..569L. doi:10.1126/science.2541503. PMID 2541503.

[pmid1662665-6] Libert F, Passage E, Parmentier M, Simons MJ, Vassart G, Mattei MG (September 1991). "Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor". Genomics. 11 (1): 225–7. doi:10.1016/0888-7543(91)90125-X. PMID 1662665.

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