Aggrecan

ACAN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MD4
Identifiers
Aliases	ACAN, AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, Aggrecan, SSOAOD
External IDs	OMIM: 155760; MGI: 99602; HomoloGene: 136177; GeneCards: ACAN; OMA:ACAN - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 88,803,436 bp[1] End 88,875,353 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D2|7 44.88 cM Start 78,703,231 bp[2] End 78,764,847 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia cartilage tissue Descending thoracic aorta popliteal artery tibial arteries tendon of biceps brachii ascending aorta middle frontal gyrus trachea Achilles tendon Top expressed in fossa condyle intercostal muscle tibiofemoral joint trachea ascending aorta ankle skin of external ear lumbar subsegment of spinal cord aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular matrix structural constituent metal ion binding protein binding hyaluronic acid binding carbohydrate binding extracellular matrix structural constituent conferring compression resistance Cellular component extracellular matrix extracellular region lysosomal lumen Golgi lumen basement membrane collagen-containing extracellular matrix perisynaptic extracellular matrix glutamatergic synapse GABA-ergic synapse Biological process skeletal system development extracellular matrix disassembly extracellular matrix organization proteolysis central nervous system development keratan sulfate catabolic process keratan sulfate biosynthetic process cell adhesion cartilage condensation chondrocyte development heart development proteoglycan biosynthetic process collagen fibril organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 176 11595 Ensembl ENSG00000157766 ENSMUSG00000030607 UniProt P16112 Q61282 RefSeq (mRNA) NM_001135 NM_013227 NM_001369268 NM_007424 NM_001361500 RefSeq (protein) NP_001126 NP_037359 NP_001356197 NP_031450 NP_001348429 Location (UCSC) Chr 15: 88.8 – 88.88 Mb Chr 7: 78.7 – 78.76 Mb PubMed search [3] [4]
Wikidata
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Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene.^[5] This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.

Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing.^[5] Aggrecan was named for its ability to form large aggregates in the cartilage tissue (a large aggregating proteoglycan).^{[6] [7]}