An anathema is something that—or someone who—is detested or shunned.
Anathema may also refer to:
- Anathema (band), a British rock band
- "Anathema", their song on Distant Satellites, a 2014 album
- "Anathema", a song by Twenty One Pilots from the 2011 album Regional at Best
- A Justice League enemy in DC comics