Angiotensin (1-7)

Angiotensin (1-7)
Angiotensin (1-7)
Identifiers
Symbol	Angiotensin (1-7)
SCOP2	2PJ8 / SCOPe / SUPFAM

Angiotensin (1-7) (C
₄₁H
₆₂N
₁₂O
₁₁; Molecular weight = 899.02 g/mol; H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH) is an active heptapeptide of the renin–angiotensin system (RAS).^{[citation needed]} It also known by the generic name talfirastide (development name TXA127).^[1]

In 1988, Santos et al demonstrated that angiotensin (1-7) was a main product of the incubation of angiotensin I with brain micropunch biopsies^[2] and Schiavone et al reported the first biological effect of this heptapeptide.^[3]

Angiotensin (1-7) is a vasodilator agent affecting cardiovascular organs, such as heart, blood vessels and kidneys, with functions frequently opposed to those attributed to the major effector component of the RAS, angiotensin II (Ang II).^[4]

^ Wagener, Gebhard; Goldklang, Monica P.; et al. (28 July 2022). "A randomized, placebo-controlled, double-blinded pilot study of angiotensin 1–7 (TXA-127) for the treatment of severe COVID-19". Critical Care. 26 (1): 229. doi:10.1186/s13054-022-04096-9. ISSN 1364-8535. PMC 9332096. PMID 35902867.
^ Santos RA, Brosnihan KB, Chappell MC, Pesquero J, Chernicky CL, Greene LJ, and Ferrario CM (1988). "Converting enzyme activity and angiotensin metabolism in the dog brainstem". Hypertension. 11 (2): 125–37. doi:10.1161/01.hyp.11.2_pt_2.i153. PMC 280369. PMID 2831145.
^ Schiavone MT, Santos RA, Brosnihan KB, Khosla MC, Ferrario CM (1988). "Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide". PNAS. 85 (11): 4095–8. Bibcode:1988PNAS...85.4095S. doi:10.1073/pnas.85.11.4095. PMC 280369. PMID 3375255.
^ Santos RA, Sampaio WO, Alzamora AC, Motta-Santos D, Alenina N, Bader M, et al. (2018). "The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7)". Physiol Rev. 1 (98): 505–553. doi:10.1152/physrev.00023.2016. PMC 7203574. PMID 29351514.

[1] Wagener, Gebhard; Goldklang, Monica P.; et al. (28 July 2022). "A randomized, placebo-controlled, double-blinded pilot study of angiotensin 1–7 (TXA-127) for the treatment of severe COVID-19". Critical Care. 26 (1): 229. doi:10.1186/s13054-022-04096-9. ISSN 1364-8535. PMC 9332096. PMID 35902867.

[2] Santos RA, Brosnihan KB, Chappell MC, Pesquero J, Chernicky CL, Greene LJ, and Ferrario CM (1988). "Converting enzyme activity and angiotensin metabolism in the dog brainstem". Hypertension. 11 (2): 125–37. doi:10.1161/01.hyp.11.2_pt_2.i153. PMC 280369. PMID 2831145.

[3] Schiavone MT, Santos RA, Brosnihan KB, Khosla MC, Ferrario CM (1988). "Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide". PNAS. 85 (11): 4095–8. Bibcode:1988PNAS...85.4095S. doi:10.1073/pnas.85.11.4095. PMC 280369. PMID 3375255.

[4] Santos RA, Sampaio WO, Alzamora AC, Motta-Santos D, Alenina N, Bader M, et al. (2018). "The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7)". Physiol Rev. 1 (98): 505–553. doi:10.1152/physrev.00023.2016. PMC 7203574. PMID 29351514.

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