Back أكسيد الزرنيخ الثلاثي Arabic آرسنیک تریاوکسید AZB Арсеник Bulgarian Òxid d'arsènic(III) Catalan Pĭ-sŏng CDO Oxid arsenitý Czech Arsenik Danish Arsen(III)-oxid German Τριοξείδιο του αρσενικού Greek Arseniko Esperanto
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| Clinical data | |
|---|---|
| Pronunciation | AR se nik tri OKS id |
| Trade names | Trisenox, others |
| Other names | Arsenic(III) oxide, Arsenic sesquioxide, Arseneous oxide, Ratsbane, Arseneous anhydride, White arsenic, Aqua Tofani[1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a608017 |
| License data | |
| Pregnancy category |
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| Routes of administration | Intravenous |
| Drug class | Antineoplastic agent |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 75% |
| Excretion | Urine |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.014.075 |
| Chemical and physical data | |
| Formula | As2O3 |
| Molar mass | 197.840 g·mol−1 |
| 3D model (JSmol) | |
| Density | 3.74 g/cm3 |
| Melting point | 312.2 °C (594.0 °F) |
| Boiling point | 465 °C (869 °F) |
| Solubility in water | 20 g/L (25 °C) (see text) |
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| Identifiers | |
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| ECHA InfoCard | 100.014.075 |
| EC Number |
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CompTox Dashboard (EPA)
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| Hazards | |
| GHS labelling:[4] | |
   
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| Danger | |
| H300, H314, H350, H410 | |
| P201, P202, P260, P264, P270, P273, P280, P301+P330+P331, P303+P361+P353, P304+P340+P310, P305+P351+P338+P310, P308+P313, P363, P391, P405, P501 | |
| Safety data sheet (SDS) | american elements SDS |
Arsenic trioxide is an inorganic compound with the formula As
2O
3.[5] As an industrial chemical, its major uses include the manufacture of wood preservatives, pesticides, and glass.[6] It is sold under the brand name Trisenox among others[2][3] when used as a medication to treat a type of cancer known as acute promyelocytic leukemia.[7] For this use it is given by injection into a vein.[7]
Common side effects include vomiting, diarrhea, swelling, shortness of breath, and headaches.[7] Severe side effects may include APL differentiation syndrome and heart problems.[7] Use during pregnancy or breastfeeding may harm the baby.[8][9] Its mechanism in treating cancer is not entirely clear.[7]
Arsenic trioxide was approved for medical use in the United States in 2000.[7] It is on the World Health Organization's List of Essential Medicines.[10] Approximately 50,000 tonnes are produced a year.[11] Due to its toxicity, a number of countries have regulations around its manufacture and sale.[12]
- ^ Shakhashiri BZ. "Chemical of the Week: Arsenic". University of Wisconsin-Madison Chemistry Dept. Archived from the original on 2 August 2008. Retrieved 3 August 2008.
- ^ a b "Trisenox- arsenic trioxide injection, solution". DailyMed. 30 June 2022. Archived from the original on 3 February 2024. Retrieved 3 February 2024.
- ^ a b "Trisenox EPAR". European Medicines Agency. 10 August 2010. Archived from the original on 16 August 2023. Retrieved 3 February 2024.
- ^ "Safety Data Sheet". American Elements. 2021. Archived from the original on 4 January 2022. Retrieved 4 January 2022.
- ^ Sun H (2010). Biological Chemistry of Arsenic, Antimony and Bismuth. John Wiley & Sons. p. 295. ISBN 9780470976227. Archived from the original on 14 April 2023. Retrieved 18 March 2023.
- ^ Landner L (2012). Chemicals in the Aquatic Environment: Advanced Hazard Assessment. Springer Science & Business Media. p. 259. ISBN 9783642613340. Archived from the original on 14 April 2023. Retrieved 18 March 2023.
- ^ a b c d e f "Arsenic Trioxide Monograph for Professionals". Drugs.com. Archived from the original on 15 November 2019. Retrieved 15 November 2019.
- ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 907. ISBN 9780857113382.
- ^ "Arsenic trioxide (Trisenox) Use During Pregnancy". Drugs.com. Archived from the original on 15 November 2019. Retrieved 16 November 2019.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ Grund SC, Hanusch K, Wolf HU. "Arsenic and Arsenic Compounds". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a03_113.pub2. ISBN 978-3527306732.
- ^ Consolidated List of Products Whose Consumption And/or Sale Have Been Banned, Withdrawn, Severely Restricted Or Not Approved by Governments: Chemicals (PDF). United Nations Publications. 2009. p. 24. ISBN 9789211302196.