Beta-3 adrenergic receptor

ADRB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CDW
Identifiers
Aliases	ADRB3, BETA3AR, adrenoceptor beta 3
External IDs	OMIM: 109691; MGI: 87939; HomoloGene: 37250; GeneCards: ADRB3; OMA:ADRB3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.23 Start 37,962,990 bp[1] End 37,966,599 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A2|8 15.94 cM Start 27,225,776 bp[2] End 27,250,616 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ovary left ovary testicle left uterine tube placenta urinary bladder gallbladder gonad muscle layer of sigmoid colon fundus Top expressed in lactiferous gland white adipose tissue brown adipose tissue tunica adventitia of aorta subcutaneous adipose tissue intercostal muscle tunica media of zone of aorta trachea mesenteric lymph nodes embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-adrenergic receptor activity G protein-coupled receptor activity epinephrine binding protein homodimerization activity beta3-adrenergic receptor activity norepinephrine binding beta-3 adrenergic receptor binding signal transducer activity adrenergic receptor activity protein binding Cellular component integral component of membrane membrane receptor complex plasma membrane integral component of plasma membrane nucleus Biological process adenylate cyclase-activating G protein-coupled receptor signaling pathway eating behavior adenylate cyclase-modulating G protein-coupled receptor signaling pathway response to antibiotic negative regulation of multicellular organism growth cell-cell signaling G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ageing receptor-mediated endocytosis generation of precursor metabolites and energy activation of adenylate cyclase activity diet induced thermogenesis norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure adenylate cyclase-activating adrenergic receptor signaling pathway heat generation brown fat cell differentiation response to cold energy reserve metabolic process temperature homeostasis desensitization of G protein-coupled receptor signaling pathway by arrestin positive regulation of MAPK cascade signal transduction carbohydrate metabolic process G protein-coupled receptor signaling pathway positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 155 11556 Ensembl ENSG00000188778 ENSMUSG00000031489 UniProt P13945 P25962 RefSeq (mRNA) NM_000025 NM_013462 RefSeq (protein) NP_000016 NP_038490 Location (UCSC) Chr 8: 37.96 – 37.97 Mb Chr 8: 27.23 – 27.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The beta-3 adrenergic receptor (β₃-adrenoceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the human gene encoding it.^[5]