Brian Clarke (born 1953) is a British painter, set-designer and architectural artist.
Brian Clarke may also refer to:
- Brian Clarke (footballer, born 1968), English former footballer
- Brian Clarke (Gaelic footballer) (born c. 1975), Irish Gaelic footballer (Kerry)
- Brian Patrick Clarke (born 1952), American actor
- Brian Clarke (author) (born 1938), English author, journalist and angler