C3a receptor

C3AR1
Identifiers
Aliases	C3AR1, AZ3B, C3AR, HNFAG09, complement component 3a receptor 1, complement C3a receptor 1
External IDs	OMIM: 605246; MGI: 1097680; HomoloGene: 2992; GeneCards: C3AR1; OMA:C3AR1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,066,359 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,833,120 bp
RNA expression pattern
	Top expressed in
	monocyte; ; trabecular bone; ; decidua; ; amniotic fluid; ; bone marrow; ; blood; ; appendix; ; lower lobe of lung; ; bone marrow cells; ; superficial temporal artery;
	Top expressed in
	stroma of bone marrow; ; calvaria; ; ankle joint; ; ankle; ; lumbar subsegment of spinal cord; ; internal carotid artery; ; external carotid artery; ; sciatic nerve; ; white adipose tissue; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; complement receptor activity; complement component C3a receptor activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; azurophil granule membrane; specific granule membrane;
Biological process	blood circulation; signal transduction; chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of macrophage chemotaxis; inflammatory response; positive regulation of vascular endothelial growth factor production; G protein-coupled receptor signaling pathway; regulation of complement activation; phospholipase C-activating G protein-coupled receptor signaling pathway; neutrophil degranulation; leukocyte migration; cell chemotaxis; complement receptor mediated signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	719
	12267
	ENSG00000171860
	ENSMUSG00000040552
	Q16581
	O09047
	NM_004054; NM_001326475; NM_001326477
	NM_009779
	NP_001313404; NP_001313406; NP_004045
	NP_033909
	Wikidata
View/Edit Human	View/Edit Mouse

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.^[5]^[6]

The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals. This has yet to be proven true in humans.^[7] C3a receptor modulates immunity,^[8] arthritis, diet-induced obesity^[9] and cancers.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171860 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040552 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
^ Ali H, Panettieri RA (February 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research. 6 (1): 19. doi:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703.
^ Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.
^ Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (October 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation. 13 (10): 2530–9. doi:10.1111/ajt.12405. PMC 3809075. PMID 24033923.
^ Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.
^ Sayegh ET, Bloch O, Parsa AT (August 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine. 3 (4): 747–58. doi:10.1002/cam4.241. PMC 4303144. PMID 24711204.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171860 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040552 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8605247-5] Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.

[pmid15723703-6] Ali H, Panettieri RA (February 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research. 6 (1): 19. doi:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703.

[pmid=_23383423-7] Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.

[8] Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (October 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation. 13 (10): 2530–9. doi:10.1111/ajt.12405. PMC 3809075. PMID 24033923.

[9] Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.

[10] Sayegh ET, Bloch O, Parsa AT (August 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine. 3 (4): 747–58. doi:10.1002/cam4.241. PMC 4303144. PMID 24711204.

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