CHRNA7

CHRNA7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5AFK, 5AFJ, 5AFL, 2MAW, 5AFN, 5AFM, 5AFH
Identifiers
Aliases	CHRNA7, CHRNA7-2, NACHRA7, cholinergic receptor nicotinic alpha 7 subunit
External IDs	OMIM: 118511; MGI: 99779; HomoloGene: 593; GeneCards: CHRNA7; OMA:CHRNA7 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	32,173,018 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	62,862,317 bp
RNA expression pattern
	Top expressed in
	testicle; ; oocyte; ; secondary oocyte; ; ganglionic eminence; ; gonad; ; ventricular zone; ; jejunal mucosa; ; retinal pigment epithelium; ; mucosa of ileum; ; prefrontal cortex;
	Top expressed in
	trigeminal nerve; ; dentate gyrus of hippocampal formation granule cell; ; lumbar spinal ganglion; ; primary visual cortex; ; tail of embryo; ; autonomic nervous system; ; superior frontal gyrus; ; sympathetic ganglion; ; paravertebral ganglia; ; tongue;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; acetylcholine binding; acetylcholine-gated cation-selective channel activity; amyloid-beta binding; acetylcholine receptor activity; ion channel activity; chloride channel regulator activity; extracellular ligand-gated ion channel activity; toxic substance binding; ligand-gated ion channel activity; transmembrane signaling receptor activity; calcium channel activity; protein binding;
Cellular component	integral component of membrane; acetylcholine-gated channel complex; postsynaptic membrane; membrane; plasma membrane; synapse; cell junction; integral component of plasma membrane; neuron projection; plasma membrane raft; postsynapse;
Biological process	response to hypoxia; cognition; cellular calcium ion homeostasis; ion transport; positive regulation of angiogenesis; ion transmembrane transport; positive regulation of cell population proliferation; transport; calcium ion transport; signal transduction; synaptic transmission, cholinergic; memory; negative regulation of tumor necrosis factor production; response to nicotine; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; positive regulation of protein phosphorylation; chemical synaptic transmission; learning or memory; short-term memory; regulation of membrane potential; synapse organization; nervous system process; sensory processing; positive regulation of ERK1 and ERK2 cascade; calcium ion transmembrane transport; acetylcholine receptor signaling pathway; dendritic spine organization; modulation of excitatory postsynaptic potential; dendrite arborization; positive regulation of long-term synaptic potentiation; regulation of neuron death; positive regulation of amyloid-beta formation; negative regulation of amyloid-beta formation; regulation of amyloid precursor protein catabolic process; response to amyloid-beta; response to acetylcholine; regulation of amyloid fibril formation; positive regulation of CoA-transferase activity; positive regulation of excitatory postsynaptic potential;
	Sources:Amigo / QuickGO
Orthologs
	1139
	11441
	ENSG00000274542; ENSG00000175344; ENSG00000282088
	ENSMUSG00000030525
	P36544
	P49582
	NM_000746; NM_001190455
	NM_007390
	NP_000737; NP_001177384
	NP_031416
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene.^[5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

^ ^a ^b ^c ENSG00000175344, ENSG00000282088 GRCh38: Ensembl release 89: ENSG00000274542, ENSG00000175344, ENSG00000282088 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030525 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chini B, Raimond E, Elgoyhen AB, Moralli D, Balzaretti M, Heinemann S (Jun 1994). "Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)". Genomics. 19 (2): 379–381. doi:10.1006/geno.1994.1075. PMID 8188270.

[refGRCh38Ensembl-1] ENSG00000175344, ENSG00000282088 GRCh38: Ensembl release 89: ENSG00000274542, ENSG00000175344, ENSG00000282088 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030525 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8188270-5] Chini B, Raimond E, Elgoyhen AB, Moralli D, Balzaretti M, Heinemann S (Jun 1994). "Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)". Genomics. 19 (2): 379–381. doi:10.1006/geno.1994.1075. PMID 8188270.

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