CYP2B6

CYP2B6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IBD, 3QOA, 3QU8, 3UA5, 4I91, 4RQL, 4RRT, 4ZV8
Identifiers
Aliases	CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450, cytochrome P450 family 2 subfamily B member 6, Cytochrome P450 2B6
External IDs	OMIM: 123930; MGI: 88598; HomoloGene: 73894; GeneCards: CYP2B6; OMA:CYP2B6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,018,398 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	25,626,049 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; buccal mucosa cell; ; mucosa of paranasal sinus; ; nasal epithelium; ; kidney tubule; ; tendon of biceps brachii; ; mucosa of ileum; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; metanephric glomerulus;
	Top expressed in
	right lung lobe; ; duodenum; ; lacrimal gland; ; parotid gland; ; submandibular gland; ; intestinal villus; ; skin of abdomen; ; Ileal epithelium; ; skin of external ear; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; arachidonic acid epoxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; metal ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; steroid hydroxylase activity; monooxygenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; cytoplasm;
Biological process	steroid metabolic process; epoxygenase P450 pathway; cellular ketone metabolic process; xenobiotic metabolic process; organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1555
	13088
	ENSG00000197408
	ENSMUSG00000030483
	P20813
	P12791
	NM_000767
	NM_009999
	NP_000758
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene.^[5] CYP2B6 is a member of the cytochrome P450 group of enzymes. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197408 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030483 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b This article incorporates public domain material from "Entrez Gene: cytochrome P450". Reference Sequence collection. National Center for Biotechnology Information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197408 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030483 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] This article incorporates public domain material from "Entrez Gene: cytochrome P450". Reference Sequence collection. National Center for Biotechnology Information.

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