CYP2C8

CYP2C8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VN0, 1PQ2, 2NNH, 2NNI, 2NNJ
Identifiers
Aliases	CYP2C8, CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM
External IDs	OMIM: 601129; MGI: 1306818; HomoloGene: 117948; GeneCards: CYP2C8; OMA:CYP2C8 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	95,069,497 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	39,556,973 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; sperm; ; pancreatic ductal cell; ; right uterine tube; ; testicle; ; gallbladder; ; anterior pituitary; ; left adrenal cortex; ; gonad; ; body of stomach;
	Top expressed in
	liver; ; thoracic diaphragm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; caffeine oxidase activity; aromatase activity; oxidoreductase activity; heme binding; metal ion binding; iron ion binding; arachidonic acid epoxygenase activity; monooxygenase activity; estrogen 16-alpha-hydroxylase activity; steroid hydroxylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;
Cellular component	endoplasmic reticulum; organelle membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum membrane; cytoplasm;
Biological process	omega-hydroxylase P450 pathway; organic acid metabolic process; epoxygenase P450 pathway; oxidative demethylation; xenobiotic metabolic process; lipid hydroxylation; steroid metabolic process; long-chain fatty acid biosynthetic process; estrogen metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1558
	13098
	ENSG00000138115
	ENSMUSG00000025003
	P10632
	P56656
	NM_000770; NM_001198853; NM_001198854; NM_001198855; NM_030878
	NM_010003; NM_001373937
	NP_000761; NP_001185782; NP_001185783; NP_001185784
	NP_034133; NP_001360866
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P₄₅₀2C8 (CYP2C8) is a member of the cytochrome P450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body. Cytochrome P₄₅₀2C8 also possesses epoxygenase activity, i.e. it metabolizes long-chain polyunsaturated fatty acids, e.g. arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and linoleic acid to their biologically active epoxides.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138115 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025003 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Westphal C, Konkel A, Schunck WH (Nov 2011). "CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?". Prostaglandins & Other Lipid Mediators. 96 (1–4): 99–108. doi:10.1016/j.prostaglandins.2011.09.001. PMID 21945326.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138115 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025003 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Westphal C, Konkel A, Schunck WH (Nov 2011). "CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?". Prostaglandins & Other Lipid Mediators. 96 (1–4): 99–108. doi:10.1016/j.prostaglandins.2011.09.001. PMID 21945326.

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