Cathepsin K

CTSK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MEM, 3KWB, 3KX1, 4X6J, 1AYW, 3KW9, 1YT7, 1AU2, 4X6H, 1Q6K, 1YK7, 1ATK, 3C9E, 1AYV, 1BGO, 4N8W, 7PCK, 4DMX, 4X6I, 1NL6, 1TU6, 3O0U, 1AU4, 3OVZ, 3KWZ, 2ATO, 3O1G, 1AU0, 1BY8, 1SNK, 2AUZ, 4DMY, 4N79, 1AYU, 1U9X, 1YK8, 1AU3, 1U9V, 2BDL, 1VSN, 1U9W, 2AUX, 2R6N, 3H7D, 1NLJ, 5J94, 4YVA, 4YV8
Identifiers
Aliases	CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD, cathepsin K
External IDs	OMIM: 601105; MGI: 107823; HomoloGene: 68053; GeneCards: CTSK; OMA:CTSK - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,809,577 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,416,673 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; skin of hip; ; stromal cell of endometrium; ; gallbladder; ; tibia; ; gastric mucosa; ; skin of thigh; ; canal of the cervix; ; decidua; ; ectocervix;
	Top expressed in
	body of femur; ; calvaria; ; decidua; ; tibiofemoral joint; ; ankle; ; skin of external ear; ; vestibular sensory epithelium; ; stroma of bone marrow; ; gastrula; ; ankle joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; cysteine-type peptidase activity; collagen binding; peptidase activity; protein binding; cysteine-type endopeptidase activity; hydrolase activity; proteoglycan binding; serine-type endopeptidase activity;
Cellular component	cytoplasm; extracellular region; endolysosome lumen; lysosome; extracellular space; nucleoplasm; intracellular membrane-bounded organelle; lysosomal lumen;
Biological process	intramembranous ossification; positive regulation of protein targeting to mitochondrion; extracellular matrix disassembly; bone resorption; proteolysis; toll-like receptor signaling pathway; regulation of autophagy of mitochondrion; collagen catabolic process; proteolysis involved in cellular protein catabolic process; regulation of keratinocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1513
	13038
	ENSG00000143387
	ENSMUSG00000028111
	P43235
	P55097
	NM_000396
	NM_007802
	NP_000387
	NP_031828
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143387 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028111 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CTSK cathepsin K".
^ Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T (January 1995). "Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone". Biochemical and Biophysical Research Communications. 206 (1): 89–96. doi:10.1006/bbrc.1995.1013. PMID 7818555.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143387 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028111 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CTSK cathepsin K".

[pmid7818555-6] Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T (January 1995). "Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone". Biochemical and Biophysical Research Communications. 206 (1): 89–96. doi:10.1006/bbrc.1995.1013. PMID 7818555.

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