Chiral resolution

Chiral resolution, or enantiomeric resolution,^[1] is a process in stereochemistry for the separation of racemic mixture into their enantiomers.^[2] It is an important tool in the production of optically active compounds, including drugs.^[3] Another term with the same meaning is optical resolution.

The use of chiral resolution to obtain enantiomerically pure compounds has the disadvantage of necessarily discarding at least half of the starting racemic mixture. Asymmetric synthesis of one of the enantiomers is one means of avoiding this waste.

^ Kuhn, Reinhard.; Erni, Fritz.; Bereuter, Thomas.; Haeusler, Johannes. (1992-11-15). "Chiral recognition and enantiomeric resolution based on host-guest complexation with crown ethers in capillary zone electrophoresis". Analytical Chemistry. 64 (22): 2815–2820. doi:10.1021/ac00046a026.
^ Smith, Michael B.; March, Jerry (2007), Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th ed.), New York: Wiley-Interscience, p. 173-179, ISBN 978-0-471-72091-1
^ William H. Porter (1991). "Resolution of chiral drugs" (PDF). Pure Appl. Chem. 63 (8): 1119–1122. doi:10.1351/pac199163081119. S2CID 35860450.

[1] Kuhn, Reinhard.; Erni, Fritz.; Bereuter, Thomas.; Haeusler, Johannes. (1992-11-15). "Chiral recognition and enantiomeric resolution based on host-guest complexation with crown ethers in capillary zone electrophoresis". Analytical Chemistry. 64 (22): 2815–2820. doi:10.1021/ac00046a026.

[2] Smith, Michael B.; March, Jerry (2007), Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th ed.), New York: Wiley-Interscience, p. 173-179, ISBN 978-0-471-72091-1

[3] William H. Porter (1991). "Resolution of chiral drugs" (PDF). Pure Appl. Chem. 63 (8): 1119–1122. doi:10.1351/pac199163081119. S2CID 35860450.

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