Disorders of sex development

Disorders of sex development
Disorders of sex development
Other names	Disorders of sex differentiation, variations of sex characteristics
Specialty	Medical genetics

Disorders of sex development (DSDs), also known as differences in sex development or variations in sex characteristics (VSC),^[2] ^[3] are congenital conditions affecting the reproductive system, in which development of chromosomal, gonadal, or anatomical sex is atypical.^[4] DSDs is a clinical term used in some medical settings for what are otherwise referred to as intersex traits. The term was first introduced in 2006 and has not been without controversy.

DSDs are subdivided into groups in which the labels generally emphasize the karyotype's role in diagnosis: 46,XX; 46,XY; sex chromosome; XX, sex reversal; ovotesticular disorder; and XY, sex reversal.^[5]

^ Diamond M, Beh HG (January 2008). "Changes in the management of children with intersex conditions". Nature Clinical Practice. Endocrinology & Metabolism. 4 (1): 4–5. doi:10.1038/ncpendmet0694. hdl:10125/66380. PMID 17984980. S2CID 13382948.
^ "Differences in sex development". U.K. National Health Service (NHS). 2017-10-18. Retrieved 2020-04-10.
^ "Information about the standard for gender, sex, and variations of sex characteristics | Stats NZ". www.stats.govt.nz. Retrieved 2024-03-12.
^ Lee PA, Houk CP, Ahmed SF, Hughes IA (August 2006). "Consensus statement on management of intersex disorders. International Consensus Conference on Intersex". Pediatrics. 118 (2): e488-500. doi:10.1542/peds.2006-0738. PMC 2082839. PMID 16882788.
^ Domenice, Sorahia; Batista, Rafael Loch; Arnhold, Ivo J.; Sircili, Maria Helena; Costa, Elaine M. F.; Mendonca, Berenice Bilharinho (2000), Feingold, Kenneth R.; Anawalt, Bradley; Boyce, Alison; Chrousos, George (eds.), "46,XY Differences of Sexual Development", Endotext, South Dartmouth (MA): MDText.com, Inc., PMID 25905393, retrieved 2023-01-20

[hawaii.edu-1] Diamond M, Beh HG (January 2008). "Changes in the management of children with intersex conditions". Nature Clinical Practice. Endocrinology & Metabolism. 4 (1): 4–5. doi:10.1038/ncpendmet0694. hdl:10125/66380. PMID 17984980. S2CID 13382948.

[NHS-2] "Differences in sex development". U.K. National Health Service (NHS). 2017-10-18. Retrieved 2020-04-10.

[3] "Information about the standard for gender, sex, and variations of sex characteristics | Stats NZ". www.stats.govt.nz. Retrieved 2024-03-12.

[lee-4] Lee PA, Houk CP, Ahmed SF, Hughes IA (August 2006). "Consensus statement on management of intersex disorders. International Consensus Conference on Intersex". Pediatrics. 118 (2): e488-500. doi:10.1542/peds.2006-0738. PMC 2082839. PMID 16882788.

[5] Domenice, Sorahia; Batista, Rafael Loch; Arnhold, Ivo J.; Sircili, Maria Helena; Costa, Elaine M. F.; Mendonca, Berenice Bilharinho (2000), Feingold, Kenneth R.; Anawalt, Bradley; Boyce, Alison; Chrousos, George (eds.), "46,XY Differences of Sexual Development", Endotext, South Dartmouth (MA): MDText.com, Inc., PMID 25905393, retrieved 2023-01-20

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