Dopamine receptor D1

DRD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OZ5
Identifiers
Aliases	DRD1, dopamine receptor D1, DADR, DRD1A
External IDs	OMIM: 126449; MGI: 99578; HomoloGene: 30992; GeneCards: DRD1; OMA:DRD1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	175,444,182 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	54,209,724 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; gonad; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; Brodmann area 46;
	Top expressed in
	nucleus accumbens; ; dorsal striatum; ; olfactory tubercle; ; globus pallidus; ; superior frontal gyrus; ; temporal lobe; ; amygdala; ; neural layer of retina; ; urethra; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dopamine neurotransmitter receptor activity; dopamine binding; protein binding; dopamine neurotransmitter receptor activity, coupled via Gs; G protein-coupled receptor activity; signal transducer activity; G-protein alpha-subunit binding;
Cellular component	membrane; nucleus; endoplasmic reticulum; integral component of membrane; plasma membrane; endoplasmic reticulum membrane; integral component of plasma membrane; ciliary membrane; endomembrane system; non-motile cilium; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; dendritic spine; dendrite; cell projection; cilium;
Biological process	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; muscle contraction; protein import into nucleus; positive regulation of potassium ion transport; response to amphetamine; learning; feeding behavior; long-term depression; temperature homeostasis; striatum development; prepulse inhibition; response to cocaine; grooming behavior; behavioral response to cocaine; locomotory behavior; dentate gyrus development; transmission of nerve impulse; memory; positive regulation of synaptic transmission, glutamatergic; synapse assembly; habituation; adult walking behavior; peristalsis; cellular response to catecholamine stimulus; adenylate cyclase-activating dopamine receptor signaling pathway; regulation of dopamine uptake involved in synaptic transmission; associative learning; astrocyte development; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; positive regulation of release of sequestered calcium ion into cytosol; mating behavior; behavioral fear response; activation of adenylate cyclase activity; dopamine receptor signaling pathway; conditioned taste aversion; cerebral cortex GABAergic interneuron migration; glucose import; visual learning; sensitization; positive regulation of cell migration; operant conditioning; vasodilation; regulation of dopamine metabolic process; dopamine metabolic process; phospholipase C-activating dopamine receptor signaling pathway; maternal behavior; dopamine transport; hippocampus development; neuronal action potential; long-term potentiation; signal transduction; synaptic transmission, dopaminergic; positive regulation of gene expression; cellular response to dopamine; regulation of protein phosphorylation; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1812
	13488
	ENSG00000184845
	ENSMUSG00000021478
	P21728
	Q61616
	NM_000794
	NM_001291801; NM_010076
	NP_000785
	NP_001278730; NP_034206
	Wikidata
View/Edit Human	View/Edit Mouse

Dopamine receptor D₁, also known as DRD1. It is one of the two types of D₁-like receptor family — receptors D₁ and D₅. It is a protein that in humans is encoded by the DRD1 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184845 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021478 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dearry A, Gingrich JA, Falardeau P, Fremeau RT, Bates MD, Caron MG (September 1990). "Molecular cloning and expression of the gene for a human D1 dopamine receptor". Nature. 347 (6288): 72–76. Bibcode:1990Natur.347...72D. doi:10.1038/347072a0. PMID 2144334. S2CID 4281682.
^ Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HH, Cone R, Pribnow D, Salon J, Bunzow JR, Civelli O (September 1990). "Cloning and expression of human and rat D1 dopamine receptors". Nature. 347 (6288): 76–80. Bibcode:1990Natur.347...76Z. doi:10.1038/347076a0. PMID 2168520. S2CID 4313577.
^ Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang YL, Israel Y (September 1990). "Human dopamine D1 receptor encoded by an intronless gene on chromosome 5". Nature. 347 (6288): 80–83. Bibcode:1990Natur.347...80S. doi:10.1038/347080a0. PMID 1975640. S2CID 4236625.
^ Mishra A, Singh S, Shukla S (2018-05-31). "Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson's disease". Journal of Experimental Neuroscience. 12: 1179069518779829. doi:10.1177/1179069518779829. PMC 5985548. PMID 29899667.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184845 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021478 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2144334-5] Dearry A, Gingrich JA, Falardeau P, Fremeau RT, Bates MD, Caron MG (September 1990). "Molecular cloning and expression of the gene for a human D1 dopamine receptor". Nature. 347 (6288): 72–76. Bibcode:1990Natur.347...72D. doi:10.1038/347072a0. PMID 2144334. S2CID 4281682.

[pmid2168520-6] Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HH, Cone R, Pribnow D, Salon J, Bunzow JR, Civelli O (September 1990). "Cloning and expression of human and rat D1 dopamine receptors". Nature. 347 (6288): 76–80. Bibcode:1990Natur.347...76Z. doi:10.1038/347076a0. PMID 2168520. S2CID 4313577.

[pmid1975640-7] Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang YL, Israel Y (September 1990). "Human dopamine D1 receptor encoded by an intronless gene on chromosome 5". Nature. 347 (6288): 80–83. Bibcode:1990Natur.347...80S. doi:10.1038/347080a0. PMID 1975640. S2CID 4236625.

[:0-8] Mishra A, Singh S, Shukla S (2018-05-31). "Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson's disease". Journal of Experimental Neuroscience. 12: 1179069518779829. doi:10.1177/1179069518779829. PMC 5985548. PMID 29899667.

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