Enterovirus 71

Enterovirus A71
	TEM micrograph of Enterovirus A71 virions. Scale bar, 50 nm.
Virus classification
(unranked):	Virus
Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Pisuviricota
Class:	Pisoniviricetes
Order:	Picornavirales
Family:	Picornaviridae
Genus:	Enterovirus
Species:	Enterovirus A
Serotype:	Enterovirus A71
Synonyms
	Enterovirus 71 (EV71); Human rhinovirus A71; Human rhinovirus 71;

Enterovirus 71 (EV71), also known as Enterovirus A71 (EV-A71), is a virus of the genus Enterovirus in the Picornaviridae family,^[1] notable for its role in causing epidemics of severe neurological disease and hand, foot, and mouth disease in children.^[2] It was first isolated and characterized from cases of neurological disease in California in 1969.^[3]^[4] Enterovirus 71 infrequently causes polio-like syndrome permanent paralysis.^[5]

^ "Human enterovirus 71 polyprotein gene, complete cds". 2001-04-30. Archived from the original on 12 December 2014. Retrieved 4 February 2020.
^ Lin TY, Chu C, Chiu CH (October 2002). "Lactoferrin inhibits enterovirus 71 infection of human embryonal rhabdomyosarcoma cells in vitro". J. Infect. Dis. 186 (8): 1161–4. doi:10.1086/343809. PMID 12355368.
^ Wang, Jen-Ren; Tuan, Yen-Chang; Tsai, Huey-Pin; Yan, Jing-Jou; Liu, Ching-Chuan; Su, Ih-Jen (January 2002). "Change of Major Genotype of Enterovirus 71 in Outbreaks of Hand-Foot-and-Mouth Disease in Taiwan between 1998 and 2000". Journal of Clinical Microbiology. 40 (1). American Society for Microbiology: 10–5. doi:10.1128/JCM.40.1.10-15.2002. PMC 120096. PMID 11773085.
^ SY Wang; CL Lin; HC Sun; HY Chen (25 December 1999). "Laboratory Investigation of a Suspected Enterovirus 71 Outbreak in Central Taiwan" (PDF). Epidemiology Bulletin. 15 (12): 215–219. Archived from the original (PDF) on 28 May 2008.
^ Schubert, Ryan D.; Hawes, Isobel A.; et al. (2019). "Pan-viral serology implicates enteroviruses in acute flaccid myelitis". Nature Medicine. 25 (11): 1748–1752. doi:10.1038/s41591-019-0613-1. PMC 6858576. PMID 31636453.

[1] "Human enterovirus 71 polyprotein gene, complete cds". 2001-04-30. Archived from the original on 12 December 2014. Retrieved 4 February 2020.

[lac-2] Lin TY, Chu C, Chiu CH (October 2002). "Lactoferrin inhibits enterovirus 71 infection of human embryonal rhabdomyosarcoma cells in vitro". J. Infect. Dis. 186 (8): 1161–4. doi:10.1086/343809. PMID 12355368.

[Taiwan-3] Wang, Jen-Ren; Tuan, Yen-Chang; Tsai, Huey-Pin; Yan, Jing-Jou; Liu, Ching-Chuan; Su, Ih-Jen (January 2002). "Change of Major Genotype of Enterovirus 71 in Outbreaks of Hand-Foot-and-Mouth Disease in Taiwan between 1998 and 2000". Journal of Clinical Microbiology. 40 (1). American Society for Microbiology: 10–5. doi:10.1128/JCM.40.1.10-15.2002. PMC 120096. PMID 11773085.

[4] SY Wang; CL Lin; HC Sun; HY Chen (25 December 1999). "Laboratory Investigation of a Suspected Enterovirus 71 Outbreak in Central Taiwan" (PDF). Epidemiology Bulletin. 15 (12): 215–219. Archived from the original (PDF) on 28 May 2008.

[5] Schubert, Ryan D.; Hawes, Isobel A.; et al. (2019). "Pan-viral serology implicates enteroviruses in acute flaccid myelitis". Nature Medicine. 25 (11): 1748–1752. doi:10.1038/s41591-019-0613-1. PMC 6858576. PMID 31636453.

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