Eukaryotic small ribosomal subunit (40S)

The eukaryotic small ribosomal subunit (40S) is the smaller subunit of the eukaryotic 80S ribosomes, with the other major component being the large ribosomal subunit (60S). The "40S" and "60S" names originate from the convention that ribosomal particles are denoted according to their sedimentation coefficients in Svedberg units. It is structurally and functionally related to the 30S subunit of 70S prokaryotic ribosomes.^[1]^[2]^[3]^[4]^[5] However, the 40S subunit is much larger than the prokaryotic 30S subunit and contains many additional protein segments, as well as rRNA expansion segments.

^ 40S+Ribosomal+Subunits at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^ Rabl, J; Leibundgut, M; Ataide, SF; Haag, A; Ban, N (Feb 2011). "Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1". Science. 331 (6018): 730–736. Bibcode:2011Sci...331..730R. doi:10.1126/science.1198308. hdl:20.500.11850/153130. PMID 21205638. S2CID 24771575.
^ Ben-Shem, A; Garreau; de Loubresse, N; Melnikov, S; Jenner, L; Yusupova, G; Yusupov, M (Dec 2011). "The structure of the eukaryotic ribosome at 3.0 Å resolution". Science. 334 (6062): 1524–1529. Bibcode:2011Sci...334.1524B. doi:10.1126/science.1212642. PMID 22096102. S2CID 9099683.
^ Wimberly, BT; Brodersen, DE; Clemons, WM Jr; Morgan-Warren, RJ; Carter, AP; Vonrhein, C; Hartsch, T; Ramakrishnan, V (Sep 2000). "Structure of the 30S ribosomal subunit". Nature. 407 (6802): 327–339. Bibcode:2000Natur.407..327W. doi:10.1038/35030006. PMID 11014182. S2CID 4419944.
^ Schmeing, TM; Ramakrishnan, V (Oct 2009). "What recent ribosome structures have revealed about the mechanism of translation". Nature. 461 (7268): 1234–1242. Bibcode:2009Natur.461.1234S. doi:10.1038/nature08403. PMID 19838167. S2CID 4398636.

[1] 40S+Ribosomal+Subunits at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[Rabl-2] Rabl, J; Leibundgut, M; Ataide, SF; Haag, A; Ban, N (Feb 2011). "Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1". Science. 331 (6018): 730–736. Bibcode:2011Sci...331..730R. doi:10.1126/science.1198308. hdl:20.500.11850/153130. PMID 21205638. S2CID 24771575.

[Ben-Shem-3] Ben-Shem, A; Garreau; de Loubresse, N; Melnikov, S; Jenner, L; Yusupova, G; Yusupov, M (Dec 2011). "The structure of the eukaryotic ribosome at 3.0 Å resolution". Science. 334 (6062): 1524–1529. Bibcode:2011Sci...334.1524B. doi:10.1126/science.1212642. PMID 22096102. S2CID 9099683.

[4] Wimberly, BT; Brodersen, DE; Clemons, WM Jr; Morgan-Warren, RJ; Carter, AP; Vonrhein, C; Hartsch, T; Ramakrishnan, V (Sep 2000). "Structure of the 30S ribosomal subunit". Nature. 407 (6802): 327–339. Bibcode:2000Natur.407..327W. doi:10.1038/35030006. PMID 11014182. S2CID 4419944.

[Schmeing-5] Schmeing, TM; Ramakrishnan, V (Oct 2009). "What recent ribosome structures have revealed about the mechanism of translation". Nature. 461 (7268): 1234–1242. Bibcode:2009Natur.461.1234S. doi:10.1038/nature08403. PMID 19838167. S2CID 4398636.

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