Back مشابه وظيفي Arabic Anàleg funcional Catalan Análogo funcional Spanish آنالوگ عملکردی (شیمی) Persian Analogue fonctionnel French 기능유사체 Korean Funkcijski analog Serbo-Croatian Funkcijski analog Serbian வேதி வினைக்குழு ஒப்புமைகள் Tamil
In chemistry and pharmacology, functional analogs are chemical compounds that have similar physical, chemical, biochemical, or pharmacological properties. Functional analogs are not necessarily structural analogs with a similar chemical structure.[1] An example of pharmacological functional analogs are morphine, heroin and fentanyl, which have the same mechanism of action, but fentanyl is structurally quite different from the other two with significant variance in dosage.[2]
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- ^ Martin, Yvonne C.; Kofron, James L.; Traphagen, Linda M. (2002). "Do Structurally Similar Molecules Have Similar Biological Activity?". Journal of Medicinal Chemistry. 45 (19): 4350–8. doi:10.1021/jm020155c. PMID 12213076.
- ^ Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 214f, 286. ISBN 3-8047-1763-2.