GLRB

GLRB
Identifiers
Aliases	GLRB, HKPX2, glycine receptor beta
External IDs	OMIM: 138492; MGI: 95751; HomoloGene: 20224; GeneCards: GLRB; OMA:GLRB - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	157,172,090 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	80,820,967 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 10; ; middle frontal gyrus; ; lateral nuclear group of thalamus; ; pons; ; paraflocculus of cerebellum; ; Brodmann area 23; ; dorsolateral prefrontal cortex; ; endothelial cell; ; primary visual cortex;
	Top expressed in
	lateral geniculate nucleus; ; mammillary body; ; pontine nuclei; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; lobe of cerebellum; ; lateral hypothalamus; ; dorsal tegmental nucleus; ; cerebellar vermis; ; lateral septal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	glycine binding; protein binding; extracellularly glycine-gated ion channel activity; chloride channel activity; extracellular ligand-gated ion channel activity; extracellularly glycine-gated chloride channel activity; ion channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	cytoplasm; integral component of membrane; postsynaptic membrane; cell projection; membrane; synapse; chloride channel complex; glycine-gated chloride channel complex; cell junction; dendrite; integral component of plasma membrane; plasma membrane; GABA-ergic synapse; glycinergic synapse; neuron projection;
Biological process	response to amino acid; startle response; protein heterooligomerization; regulation of membrane potential; gamma-aminobutyric acid receptor clustering; chloride transmembrane transport; nervous system development; acrosome reaction; neuromuscular process; righting reflex; chloride transport; neuropeptide signaling pathway; visual perception; adult walking behavior; ion transport; synaptic transmission, glycinergic; excitatory postsynaptic potential; chemical synaptic transmission; ion transmembrane transport; signal transduction; nervous system process; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2743
	14658
	ENSG00000109738
	ENSMUSG00000028020
	P48167
	P48168
	NM_000824; NM_001166060; NM_001166061
NM_001281969; NM_010298; NM_001345955; NM_001345956; NM_001345957;
	NM_001345958; NM_001345959; NM_001345996
	NP_000815; NP_001159532; NP_001159533
NP_001268898; NP_001332884; NP_001332885; NP_001332886; NP_001332887;
	NP_001332888; NP_001332925; NP_034428
	Wikidata
View/Edit Human	View/Edit Mouse

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.^[5]^[6]^[7]

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109738 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028020 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics. 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID 9676428.
^ Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res. 35 (1–2): 211–9. doi:10.1016/0169-328x(95)00218-h. PMID 8717357.
^ ^a ^b "Entrez Gene: GLRB glycine receptor, beta".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109738 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028020 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9676428-5] Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics. 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID 9676428.

[pmid8717357-6] Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res. 35 (1–2): 211–9. doi:10.1016/0169-328x(95)00218-h. PMID 8717357.

[entrez-7] "Entrez Gene: GLRB glycine receptor, beta".

[1]

[2]

[3]

[4]

[5]

[6]

[7]