GNAI1

GNAI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q, 5JS7, 5JS8
Identifiers
Aliases	GNAI1, Gi, G protein subunit alpha i1, HG1B, NEDHISB
External IDs	OMIM: 139310; MGI: 95771; HomoloGene: 74417; GeneCards: GNAI1; OMA:GNAI1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	80,226,181 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	18,565,353 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; inferior ganglion of vagus nerve; ; pars reticulata; ; subthalamic nucleus; ; germinal epithelium; ; C1 segment; ; pons; ; oocyte; ; secondary oocyte; ; superior vestibular nucleus;
	Top expressed in
	substantia nigra; ; lateral septal nucleus; ; subiculum; ; barrel cortex; ; sciatic nerve; ; nucleus accumbens; ; white adipose tissue; ; Region I of hippocampus proper; ; cerebellar vermis; ; lobe of cerebellum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activating protein binding; nucleotide binding; G-protein beta/gamma-subunit complex binding; GDP binding; G protein-coupled serotonin receptor binding; signal transducer activity; metal ion binding; protein binding; guanyl nucleotide binding; G protein-coupled receptor binding; GTP binding; magnesium ion binding; GTPase activity;
Cellular component	cytoplasm; centrosome; membrane; plasma membrane; intracellular anatomical structure; microtubule organizing center; lysosomal membrane; midbody; heterotrimeric G-protein complex; membrane raft; extracellular exosome; cytoskeleton; nucleus; nucleolus; cell cortex region; cell cortex; protein-containing complex;
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; response to peptide hormone; negative regulation of synaptic transmission; cell division; cell cycle; signal transduction; regulation of cAMP-mediated signaling; cellular response to forskolin; protein folding; regulation of mitotic spindle organization; positive regulation of protein localization to cell cortex; transport; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2770
	14677
	ENSG00000127955
	ENSMUSG00000057614
	P63096
	B2RSH2
	NM_002069; NM_001256414
	NM_010305
	NP_001243343; NP_002060
	NP_034435
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127955 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057614 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5115–9. Bibcode:1987PNAS...84.5115B. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783.
^ "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127955 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057614 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3110783-5] Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5115–9. Bibcode:1987PNAS...84.5115B. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783.

[6] "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".

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