GNAZ

GNAZ
Identifiers
Aliases	GNAZ, G protein subunit alpha z, gz-alpha, HG1H
External IDs	OMIM: 139160; MGI: 95780; HomoloGene: 22574; GeneCards: GNAZ; OMA:GNAZ - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,125,032 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	74,852,739 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; paraflocculus of cerebellum; ; middle temporal gyrus; ; C1 segment; ; middle frontal gyrus; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; anterior cingulate cortex;
	Top expressed in
	ventromedial nucleus; ; anterior amygdaloid area; ; lateral septal nucleus; ; mammillary body; ; lateral hypothalamus; ; subiculum; ; dorsomedial hypothalamic nucleus; ; arcuate nucleus; ; prefrontal cortex; ; median eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; G-protein beta/gamma-subunit complex binding; signal transducer activity; metal ion binding; guanyl nucleotide binding; GTP binding; G protein-coupled receptor binding; GTPase activity; protein binding; G protein-coupled serotonin receptor binding;
Cellular component	cell body; cytosol; nuclear envelope; membrane; plasma membrane; dendrite; endoplasmic reticulum; heterotrimeric G-protein complex;
Biological process	G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; signal transduction; protein folding;
	Sources:Amigo / QuickGO
Orthologs
	2781
	14687
	ENSG00000128266
	ENSMUSG00000040009
	P19086
	O70443
	NM_002073
	NM_010311; NM_001358848
	NP_002064
	NP_034441; NP_001345777
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128266 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040009 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matsuoka M, Itoh H, Kaziro Y (September 1990). "Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein". J. Biol. Chem. 265 (22): 13215–20. doi:10.1016/S0021-9258(19)38287-0. PMID 2115889.
^ "Entrez Gene: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128266 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040009 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2115889-5] Matsuoka M, Itoh H, Kaziro Y (September 1990). "Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein". J. Biol. Chem. 265 (22): 13215–20. doi:10.1016/S0021-9258(19)38287-0. PMID 2115889.

[entrez-6] "Entrez Gene: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide".

[1]

[2]

[3]

[4]

[5]

[6]