GNRHR

GNRHR
Identifiers
Aliases	GNRHR, GNRHR1, GRHR, HH7, LHRHR, LRHR, gonadotropin releasing hormone receptor
External IDs	OMIM: 138850; MGI: 95790; HomoloGene: 350; GeneCards: GNRHR; OMA:GNRHR - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 67,737,118 bp[1] End 67,754,388 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E1|5 43.56 cM Start 86,328,613 bp[2] End 86,345,760 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary testicle ganglionic eminence ventricular zone sural nerve tibialis anterior muscle prefrontal cortex corpus callosum gonad deltoid muscle Top expressed in lumbar subsegment of spinal cord pituitary gland embryo anterior pituitary right ventricle vastus lateralis muscle central gray substance of midbrain lumbar spinal ganglion digastric muscle nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-hormone receptor activity signal transducer activity G protein-coupled receptor activity peptide binding gonadotropin-releasing hormone receptor activity Cellular component plasma membrane membrane integral component of membrane integral component of plasma membrane Biological process multicellular organism development signal transduction G protein-coupled receptor signaling pathway cellular response to gonadotropin-releasing hormone cellular response to hormone stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2798 14715 Ensembl ENSG00000109163 ENSMUSG00000029255 UniProt P30968 Q01776 RefSeq (mRNA) NM_001012763 NM_000406 NM_010323 NM_001310651 NM_001310653 RefSeq (protein) NP_000397 NP_001012781 NP_001297580 NP_001297582 NP_034453 Location (UCSC) Chr 4: 67.74 – 67.75 Mb Chr 5: 86.33 – 86.35 Mb PubMed search [3] [4]
Wikidata
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Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene.^[5][6]

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.^[6]