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GTPase

GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP).[1] The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a protein domain common to many GTPases.[1]

  1. ^ a b Stouten, PF; Sander, C; Wittinghofer, A; Valencia, A (1993). "How does the switch II region of G-domains work?". FEBS Letters. 320 (1): 1–6. doi:10.1016/0014-5793(93)81644-f. PMID 8462668.

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