Back Gassmanova syntéza indolů Czech Gassman-Indol-Synthese German Síntesis de indoles de Gassman Spanish سنتز ایندول گاسمن Persian Synthèse d'indole de Gassman French Sintesi di Gassman dell'indolo Italian 加斯曼吲哚合成 Chinese
The Gassman indole synthesis is a series of chemical reactions used to synthesize substituted indoles by addition of an aniline and a ketone bearing a thioether substituent.
This is a one-pot chemical reaction, and none of the intermediates are isolated. R1 can be hydrogen or alkyl, while R2 works best with aryl, but can also be alkyl. Electron-rich anilines, such as 4-methoxyaniline, tend to fail in this reaction.
The 3-position thiomethyl group is often removed using Raney nickel to give the 3-H-indole.