Gastric inhibitory polypeptide receptor

GIPR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HJ0, 2QKH
Identifiers
Aliases	GIPR, PGQTL2, gastric inhibitory polypeptide receptor
External IDs	OMIM: 137241; MGI: 1352753; HomoloGene: 20081; GeneCards: GIPR; OMA:GIPR - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,683,722 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	18,900,052 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; apex of heart; ; right auricle; ; olfactory zone of nasal mucosa; ; body of pancreas; ; granulocyte; ; body of stomach; ; islet of Langerhans; ; minor salivary glands; ; bronchial epithelial cell;
	Top expressed in
	islet of Langerhans; ; embryo; ; morula; ; spermatid; ; blastocyst; ; ventricular zone; ; ganglionic eminence; ; left lung lobe; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; gastric inhibitory peptide receptor activity; transmembrane signaling receptor activity; protein binding; peptide hormone binding; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	response to fatty acid; response to nutrient; regulation of insulin secretion; positive regulation of cytosolic calcium ion concentration; response to glucose; generation of precursor metabolites and energy; activation of adenylate cyclase activity; response to calcium ion; cell surface receptor signaling pathway; gastric inhibitory peptide signaling pathway; response to axon injury; desensitization of G protein-coupled receptor signaling pathway; endocrine pancreas development; signal transduction; positive regulation of insulin secretion; G protein-coupled receptor signaling pathway; positive regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	2696
	381853
	ENSG00000010310
	ENSMUSG00000030406
	P48546
	Q0P543
	NM_000164; NM_001308418
	NM_001080815
	NP_000155; NP_001295347
	NP_001074284
	Wikidata
View/Edit Human	View/Edit Mouse

The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene.^[5]^[6]

GIP-R is a member of the class B family of G protein coupled receptors.^[7] GIP-R is found on beta-cells in the pancreas^[8]^[9] where it serves as the receptor for the hormone Gastric inhibitory polypeptide (GIP).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000010310 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030406 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: gastric inhibitory polypeptide receptor".
^ Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109.
^ NCBI, NCBI Gene entry 2696 (GIPR), retrieved 2018-12-20.
^ "Gastrointestinal Hormones and Peptides". Archived from the original on 2007-12-06. Retrieved 2007-08-24.
^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000010310 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030406 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: gastric inhibitory polypeptide receptor".

[pmid7490109-6] Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109.

[NCBI-Gene-2696-7] NCBI, NCBI Gene entry 2696 (GIPR), retrieved 2018-12-20.

[Helmenstine-8] "Gastrointestinal Hormones and Peptides". Archived from the original on 2007-12-06. Retrieved 2007-08-24.

[pmid12529935-9] Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935.

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