Back تحرير جيني Arabic বংশাণুসমগ্র সম্পাদনা Bengali/Bangla Edició del genoma Catalan Genome Editing German Edición de genoma Spanish مهندسی ژنوم Persian Édition génomique French Edición xenómica Galician Գենոմի փոփոխում Armenian Penyuntingan genom ID

Genome editing

The different generations of nucleases used for genome editing and the DNA repair pathways used to modify target DNA.

Genome editing, or genome engineering, or gene editing, is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the genome of a living organism. Unlike early genetic engineering techniques that randomly inserts genetic material into a host genome, genome editing targets the insertions to site-specific locations. The basic mechanism involved in genetic manipulations through programmable nucleases is the recognition of target genomic loci and binding of effector DNA-binding domain (DBD), double-strand breaks (DSBs) in target DNA by the restriction endonucleases (FokI and Cas), and the repair of DSBs through homology-directed recombination (HDR) or non-homologous end joining (NHEJ).[1][2]

  1. ^ Saurabh S (March 2021). "Genome Editing: Revolutionizing the Crop Improvement". Plant Molecular Biology Reporte. 39 (4): 752–772. doi:10.1007/s11105-021-01286-7. S2CID 233713026.
  2. ^ Bak, Rasmus O.; Gomez-Ospina, Natalia; Porteus, Matthew H. (August 2018). "Gene Editing on Center Stage". Trends in Genetics. 34 (8): 600–611. doi:10.1016/j.tig.2018.05.004. ISSN 0168-9525. PMID 29908711. S2CID 49269023.

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