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Hemoglobin A

The structure of adult human hemoglobin. α and β subunits are shown in red and blue, and the iron-containing heme groups in green. From PDB: 1GZX Proteopedia Hemoglobin.

Hemoglobin A (HbA), also known as adult hemoglobin, hemoglobin A1 or α2β2, is the most common human hemoglobin tetramer, accounting for over 97% of the total red blood cell hemoglobin.[1] Hemoglobin is an oxygen-binding protein, found in erythrocytes, which transports oxygen from the lungs to the tissues.[2] Hemoglobin A is the most common adult form of hemoglobin and exists as a tetramer containing two alpha subunits and two beta subunits (α2β2).[3] Hemoglobin A2 (HbA2) is a less common adult form of hemoglobin and is composed of two alpha and two delta-globin subunits. This hemoglobin makes up 1-3% of hemoglobin in adults.[4]

  1. ^ "Hemoglobinopathies". Retrieved 2009-02-06.
  2. ^ Farid, Yostina; Lecat, Paul (2019), "Biochemistry, Hemoglobin Synthesis", StatPearls, StatPearls Publishing, PMID 30725597, retrieved 2019-04-10
  3. ^ Immigrant medicine. Walker, Patricia Frye., Barnett, Elizabeth D. (Elizabeth Day). St. Louis, Mo.: Elsevier Mosby. 2007. ISBN 9780323034548. OCLC 489070888.{{cite book}}: CS1 maint: others (link)
  4. ^ Kato, Gregory J.; Piel, Frédéric B.; Reid, Clarice D.; Gaston, Marilyn H.; Ohene-Frempong, Kwaku; Krishnamurti, Lakshmanan; Smith, Wally R.; Panepinto, Julie A.; Weatherall, David J. (2018-03-15). "Sickle cell disease" (PDF). Nature Reviews Disease Primers. 4: 18010. doi:10.1038/nrdp.2018.10. hdl:10044/1/57817. ISSN 2056-676X. PMID 29542687. S2CID 3870507.

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