Hosokawa Yoriyuki (細川 頼之, 1329 – March 25, 1392) was a samurai of the Hosokawa clan, and prominent government minister under the Ashikaga shogunate, serving as Kyoto Kanrei (Shōgun's Deputy in Kyoto) from 1367 to 1379. The first to hold this post, he solidified the power of the shogunate, as well as elements of its administrative organization. He was also Constable (Shugo) of the provinces of Sanuki, Tosa, and Settsu. His childhood name was Yakuro (弥九郎).