IKBKG

IKBKG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JVX, 2JVY, 3BRT, 3BRV, 3CL3, 3FX0, 4BWN, 5AAY
Identifiers
Aliases	IKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKKAP1, IKKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, inhibitor of nuclear factor kappa B kinase subunit gamma, EDAID1, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
External IDs	OMIM: 300248; MGI: 1338074; HomoloGene: 2698; GeneCards: IKBKG; OMA:IKBKG - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,541,199 bp[1] End 154,565,046 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 73,436,896 bp[2] End 73,497,460 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen right lobe of liver upper lobe of left lung right adrenal cortex left adrenal gland left adrenal cortex monocyte right lung Top expressed in left lobe of liver neural layer of retina blood endothelial cell of lymphatic vessel granulocyte dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord transitional epithelium of urinary bladder stroma of bone marrow cardiac muscle tissue of left ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein domain specific binding signal transducer activity metal ion binding protein binding linear polyubiquitin binding ubiquitin protein ligase binding identical protein binding K63-linked polyubiquitin modification-dependent protein binding peroxisome proliferator activated receptor binding protein heterodimerization activity Cellular component cytoplasm spindle pole ubiquitin ligase complex intracellular anatomical structure IkappaB kinase complex mitotic spindle nucleus cytosol nucleoplasm Biological process regulation of transcription, DNA-templated regulation of tumor necrosis factor-mediated signaling pathway response to virus stimulatory C-type lectin receptor signaling pathway transcription, DNA-templated TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway JNK cascade positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade immune response positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response inflammatory response viral process I-kappaB kinase/NF-kappaB signaling T cell receptor signaling pathway nucleotide-binding oligomerization domain containing signaling pathway establishment of vesicle localization positive regulation of transcription by RNA polymerase II negative regulation of neuron death apoptotic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent cellular response to DNA damage stimulus positive regulation of macroautophagy protein deubiquitination anoikis MyD88-independent toll-like receptor signaling pathway interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8517 16151 Ensembl ENSG00000269335 ENSMUSG00000004221 UniProt Q9Y6K9 O88522 RefSeq (mRNA) NM_001099856 NM_001099857 NM_001145255 NM_003639 NM_001321396 NM_001321397 NM_001377312 NM_001377313 NM_001377314 NM_001377315 NM_001136067 NM_001161421 NM_001161422 NM_001161423 NM_001161424 NM_010547 NM_178590 RefSeq (protein) NP_001093326 NP_001093327 NP_001138727 NP_001308325 NP_001308326 NP_003630 NP_001364241 NP_001364242 NP_001364243 NP_001364244 NP_001129539 NP_001154893 NP_001154894 NP_001154895 NP_001154896 NP_034677 NP_848705 Location (UCSC) Chr X: 154.54 – 154.57 Mb Chr X: 73.44 – 73.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB.^[5] The human gene for IKBKG is located on the chromosome band Xq28.^[6] Multiple transcript variants encoding different isoforms have been found for this gene.