KCNA4

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Potassium channel Kv1.4 tandem inactivation domain
Potassium channel Kv1.4 tandem inactivation domain
	solution structure of the tandem inactivation domain (residues 1-75) of potassium channel rck4 (kv1.4)
Identifiers
Symbol	K_channel_TID
Pfam	PF07941
InterPro	IPR012897
SCOP2	1kn7 / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

KCNA4
Identifiers
Aliases	KCNA4, HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2, potassium voltage-gated channel subfamily A member 4, MCIDDS
External IDs	OMIM: 176266; MGI: 96661; HomoloGene: 20514; GeneCards: KCNA4; OMA:KCNA4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	30,017,030 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	107,128,847 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; secondary oocyte; ; caudate nucleus; ; left adrenal cortex; ; putamen; ; prefrontal cortex; ; right adrenal gland; ; right adrenal cortex; ; ventricular zone; ; paraflocculus of cerebellum;
	Top expressed in
	nucleus accumbens; ; lumbar spinal ganglion; ; medial geniculate nucleus; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; olfactory tubercle; ; substantia nigra; ; globus pallidus; ; mammillary body; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; potassium ion binding; voltage-gated ion channel activity; ion channel activity; protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity;
Cellular component	integral component of membrane; cell projection; membrane; voltage-gated potassium channel complex; plasma membrane; axon; integral component of plasma membrane; dendritic spine;
Biological process	regulation of ion transmembrane transport; ion transport; potassium ion transport; transmembrane transport; potassium ion transmembrane transport; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	3739
	16492
	ENSG00000182255
	ENSMUSG00000042604
	P22459
	Q61423
	NM_002233
	NM_021275
	NP_002224
	NP_067250
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily A member 4 also known as K_v1.4 is a protein that in humans is encoded by the KCNA4 gene.^[5]^[6]^[7] It contributes to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182255 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042604 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Philipson LH, Schaefer K, LaMendola J, Bell GI, Steiner DF (December 1990). "Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4". Nucleic Acids Research. 18 (23): 7160. doi:10.1093/nar/18.23.7160. PMC 332806. PMID 2263489.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, et al. (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ "Entrez Gene: KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4".
^ Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". Journal of Molecular and Cellular Cardiology. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410. S2CID 829154.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182255 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042604 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2263489-5] Philipson LH, Schaefer K, LaMendola J, Bell GI, Steiner DF (December 1990). "Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4". Nucleic Acids Research. 18 (23): 7160. doi:10.1093/nar/18.23.7160. PMC 332806. PMID 2263489.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, et al. (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[entrez-7] "Entrez Gene: KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4".

[oudit-8] Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". Journal of Molecular and Cellular Cardiology. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410. S2CID 829154.

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