Kir2.1

KCNJ2
Identifiers
Aliases	KCNJ2, ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3, potassium voltage-gated channel subfamily J member 2, potassium inwardly rectifying channel subfamily J member 2
External IDs	OMIM: 600681; MGI: 104744; HomoloGene: 20249; GeneCards: KCNJ2; OMA:KCNJ2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	70,180,044 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	110,967,647 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; Skeletal muscle tissue of rectus abdominis; ; dorsal motor nucleus of vagus nerve; ; Skeletal muscle tissue of biceps brachii; ; pons; ; myocardium of left ventricle; ; subthalamic nucleus; ; corpus callosum; ; superior vestibular nucleus; ; inferior olivary nucleus;
	Top expressed in
	muscle of thigh; ; granulocyte; ; genital tubercle; ; superior frontal gyrus; ; lip; ; primary visual cortex; ; temporal muscle; ; dentate gyrus of hippocampal formation granule cell; ; esophagus; ; upper arm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; voltage-gated ion channel activity; identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; inward rectifier potassium channel activity; G-protein activated inward rectifier potassium channel activity;
Cellular component	integral component of membrane; rough endoplasmic reticulum; Golgi apparatus; membrane; intercalated disc; T-tubule; voltage-gated potassium channel complex; plasma membrane; dendritic spine; integral component of plasma membrane; smooth endoplasmic reticulum; soma; dendrite; intrinsic component of membrane;
Biological process	cardiac muscle cell action potential; regulation of ion transmembrane transport; magnesium ion transport; cardiac muscle cell action potential involved in contraction; ion transport; cellular potassium ion homeostasis; potassium ion transport; regulation of cardiac muscle cell contraction; cellular response to mechanical stimulus; membrane repolarization during action potential; potassium ion transmembrane transport; positive regulation of potassium ion transmembrane transport; regulation of skeletal muscle contraction via regulation of action potential; regulation of resting membrane potential; regulation of membrane repolarization; relaxation of skeletal muscle; regulation of heart rate by cardiac conduction; membrane repolarization during cardiac muscle cell action potential; protein homotetramerization; relaxation of cardiac muscle; membrane depolarization during cardiac muscle cell action potential; potassium ion import across plasma membrane; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	3759
	16518
	ENSG00000123700
	ENSMUSG00000041695
	P63252
	P35561
	NM_000891
	NM_008425
	NP_000882
	NP_032451
	Wikidata
View/Edit Human	View/Edit Mouse

The K_ir2.1 inward-rectifier potassium channel is a lipid-gated ion channel encoded by the KCNJ2 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123700 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041695 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hansen SB (May 2015). "Lipid agonism: The PIP2 paradigm of ligand-gated ion channels". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851 (5): 620–8. doi:10.1016/j.bbalip.2015.01.011. PMC 4540326. PMID 25633344.
^ Raab-Graham KF, Radeke CM, Vandenberg CA (1994). "Molecular cloning and expression of a human heart inward rectifier potassium channel". NeuroReport. 5 (18): 2501–5. doi:10.1097/00001756-199412000-00024. PMID 7696590.
^ Derst C, Karschin C, Wischmeyer E, Hirsch JR, Preisig-Müller R, Rajan S, Engel H, Grzeschik K, Daut J, Karschin A (2001). "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. Bibcode:2001FEBSL.491..305D. doi:10.1016/S0014-5793(01)02202-5. PMID 11240146. S2CID 14452157.
^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123700 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041695 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Hansen SB (May 2015). "Lipid agonism: The PIP2 paradigm of ligand-gated ion channels". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851 (5): 620–8. doi:10.1016/j.bbalip.2015.01.011. PMC 4540326. PMID 25633344.

[pmid7696590-6] Raab-Graham KF, Radeke CM, Vandenberg CA (1994). "Molecular cloning and expression of a human heart inward rectifier potassium channel". NeuroReport. 5 (18): 2501–5. doi:10.1097/00001756-199412000-00024. PMID 7696590.

[pmid11240146-7] Derst C, Karschin C, Wischmeyer E, Hirsch JR, Preisig-Müller R, Rajan S, Engel H, Grzeschik K, Daut J, Karschin A (2001). "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. Bibcode:2001FEBSL.491..305D. doi:10.1016/S0014-5793(01)02202-5. PMID 11240146. S2CID 14452157.

[pmid16382105-8] Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.

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