Nethanel ben Isaiah (fl. 14th century) was a Yemenite Jewish rabbi, Biblical commentator and poet of the fourteenth century. He is best known as the author of a homiletic commentary on the Torah entitled Nur al-Zulm wa-Mashbah al-Hikm, translated into Hebrew as Sefer Me'or ha-Afelah (Hebrew: ספר מאור האפלה).