| Neural fold | |
|---|---|
 Chick embryo of thirty-three hours’ incubation, viewed from the dorsal aspect. 30x. (Neural fold labeled at center left, third from the bottom.) | |
| Details | |
| Carnegie stage | 9 |
| Precursor | Neural plate |
| Gives rise to | Neural tube |
| Identifiers | |
| Latin | plica neuralis |
| TE | fold_by_E5.13.1.0.1.0.2 E5.13.1.0.1.0.2 |
| Anatomical terminology | |
The neural fold is a structure that arises during neurulation in the embryonic development of both birds and mammals among other organisms.[1][2] This structure is associated with primary neurulation, meaning that it forms by the coming together of tissue layers, rather than a clustering, and subsequent hollowing out, of individual cells (known as secondary neurulation). In humans, the neural folds are responsible for the formation of the anterior end of the neural tube. The neural folds are derived from the neural plate, a preliminary structure consisting of elongated ectoderm cells. The folds give rise to neural crest cells, as well as bringing about the formation of the neural tube.[1][3]
- ^ a b Gilbert, Scott F. (2010). Developmental biology (9th ed.). Sunderland, Mass.: Sinauer Associates. ISBN 978-0878933846.[page needed]
- ^ Colas JF, Schoenwolf GC (June 2001). "Towards a cellular and molecular understanding of neurulation". Developmental Dynamics. 221 (2): 117–45. doi:10.1002/dvdy.1144. PMID 11376482. S2CID 43666547.
- ^ Yamaguchi Y, Miura M (September 2013). "How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals". Cellular and Molecular Life Sciences. 70 (17): 3171–86. doi:10.1007/s00018-012-1227-7. PMC 3742426. PMID 23242429.