Nitrogen mustard

HN2 (bis(2-chloroethyl)methylamine, mustine)

Nitrogen mustards (NMs) are cytotoxic organic compounds with the bis(2-chloroethyl)amino ((ClC₂H₄)₂NR) functional group.^[1] Although originally produced as chemical warfare agents,^[2]^[3] they were the first chemotherapeutic agents for treatment of cancer.^[4] Nitrogen mustards are nonspecific DNA alkylating agents.

^ "Mustards". The IUPAC Compendium of Chemical Terminology. 2014. doi:10.1351/goldbook.M04071.
^ Nitrogen mustard gas was stockpiled by several nations during the Second World War, but it was never used in combat.Daniel C. Keyes; Jonathan L. Burstein; Richard B. Schwartz; Raymond E. Swienton (2004). Medical Response to Terrorism: Preparedness and Clinical Practice. Lippincott Williams & Wilkins. p. 16. ISBN 978-0781749862 – via books.google.com.
^ Centers for Disease Control and Prevention (April 4, 2013). "Facts About Nitrogen Mustards". cdc.gov. Archived from the original on September 3, 2013. Retrieved September 12, 2013.
^ Chabner, Bruce A.; Roberts, Thomas G. (2005). "Chemotherapy and the war on cancer". Nature Reviews Cancer. 5 (1): 65–72. doi:10.1038/nrc1529. PMID 15630416. S2CID 205467419.

[1] "Mustards". The IUPAC Compendium of Chemical Terminology. 2014. doi:10.1351/goldbook.M04071.

[2] Nitrogen mustard gas was stockpiled by several nations during the Second World War, but it was never used in combat.Daniel C. Keyes; Jonathan L. Burstein; Richard B. Schwartz; Raymond E. Swienton (2004). Medical Response to Terrorism: Preparedness and Clinical Practice. Lippincott Williams & Wilkins. p. 16. ISBN 978-0781749862 – via books.google.com.

[3] Centers for Disease Control and Prevention (April 4, 2013). "Facts About Nitrogen Mustards". cdc.gov. Archived from the original on September 3, 2013. Retrieved September 12, 2013.

[4] Chabner, Bruce A.; Roberts, Thomas G. (2005). "Chemotherapy and the war on cancer". Nature Reviews Cancer. 5 (1): 65–72. doi:10.1038/nrc1529. PMID 15630416. S2CID 205467419.

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