O'Hare International Airport is a major airport in Chicago.
O'Hare may also refer to:
- USS O'Hare (DD-889), a US Navy destroyer
- O'Hare (surname), a surname (and list of people with the name)
- Edward O'Hare, a U.S. Naval aviator and the namesake of the airport and the ship
- O'Hare, Chicago, a US community area
- O'Hare (band), a Yugoslav 1960s rock band
- O'Hare Air, a fictional company in The Lorax (film).