Plasmin

PLG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B2I, 1BML, 1BUI, 1CEA, 1CEB, 1DDJ, 1HPJ, 1HPK, 1I5K, 1KI0, 1KRN, 1L4D, 1L4Z, 1PK4, 1PKR, 1PMK, 1QRZ, 1RJX, 2DOH, 2DOI, 2KNF, 2L0S, 2PK4, 3UIR, 4A5T, 4CIK, 4DCB, 4DUR, 4DUU, 5HPG
Identifiers
Aliases	PLG, plasminogen, plasmin, HAE4
External IDs	OMIM: 173350; MGI: 97620; HomoloGene: 55452; GeneCards: PLG; OMA:PLG - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q26 Start 160,702,238 bp[1] End 160,754,097 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 8.5 cM Start 12,597,495 bp[2] End 12,638,272 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney tubule metanephric glomerulus human kidney Descending thoracic aorta ascending aorta testicle tibial nerve right coronary artery gonad Top expressed in left lobe of liver gallbladder human fetus yolk sac fetal liver hematopoietic progenitor cell sexually immature organism abdominal wall primitive streak embryo thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function apolipoprotein binding protein domain specific binding peptidase activity protein binding serine-type peptidase activity signaling receptor binding hydrolase activity serine-type endopeptidase activity chaperone binding proteasome core complex binding protein antigen binding endopeptidase activity enzyme binding kinase binding Cellular component blood microparticle extracellular region cell surface extrinsic component of external side of plasma membrane extracellular exosome platelet alpha granule lumen extracellular space plasma membrane extrinsic component of plasma membrane intracellular membrane-bounded organelle collagen-containing extracellular matrix Biological process hemostasis negative regulation of cell-substrate adhesion negative regulation of fibrinolysis negative regulation of cell-cell adhesion mediated by cadherin platelet degranulation extracellular matrix disassembly positive regulation of fibrinolysis tissue remodeling negative regulation of cell population proliferation blood coagulation proteolysis fibrinolysis positive regulation of blood vessel endothelial cell migration tissue regeneration myoblast differentiation muscle cell cellular homeostasis proteolysis involved in cellular protein catabolic process trophoblast giant cell differentiation labyrinthine layer blood vessel development mononuclear cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5340 18815 Ensembl ENSG00000122194 ENSMUSG00000059481 UniProt P00747 P20918 RefSeq (mRNA) NM_001168338 NM_000301 NM_008877 RefSeq (protein) NP_000292 NP_001161810 NP_032903 Location (UCSC) Chr 6: 160.7 – 160.75 Mb Chr 17: 12.6 – 12.64 Mb PubMed search [3] [4]
Wikidata
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Plasmin is an important enzyme (EC 3.4.21.7) present in blood that degrades many blood plasma proteins, including fibrin clots. The degradation of fibrin is termed fibrinolysis. In humans, the plasmin protein (in the zymogen form of plasminogen) is encoded by the PLG gene.^[5]