A pragmatic clinical trial (PCT), sometimes called a practical clinical trial (PCT),[1] is a clinical trial that focuses on correlation between treatments and outcomes in real-world health system practice rather than focusing on proving causative explanations for outcomes, which requires extensive deconfounding with inclusion and exclusion criteria so strict that they risk rendering the trial results irrelevant to much of real-world practice.[2][3]
- ^ Tunis, SR; Stryer, DB; Clancy, CM (2003), "Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy", JAMA, 290 (12): 1624–1632, doi:10.1001/jama.290.12.1624, PMID 14506122.
- ^ Mullins, CD; Whicher, D; Reese, ES; Tunis, S; et al. (2010), "Generating evidence for comparative effectiveness research using more pragmatic randomized controlled trials", Pharmacoeconomics, 28 (10): 969–976, doi:10.2165/11536160-000000000-00000, PMID 20831305, S2CID 33592391.
- ^ Schwartz, D; Lellouch, J; et al. (1967), "Explanatory and pragmatic attitudes in therapeutical trials", J Chronic Dis, 20 (8): 637–648, doi:10.1016/0021-9681(67)90041-0, PMID 4860352.