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The River Wye is the fourth-longest river in the UK and forms part of the border between England and Wales.
River Wye or Wye River may also refer to:
Rivers:
- River Wye, Derbyshire, a river flowing from Axe Edge Moor, Buxton to the River Derwent
- River Wye, Buckinghamshire, a river flowing from the Chiltern Hills in Buckinghamshire down to Bourne End where it meets the Thames
- Wye River (Maryland), a tributary of the Chesapeake Bay, on the Eastern Shore of Maryland, United States
- Wye River (New Zealand), a minor river in the South Island of New Zealand
- Wye River (Tasmania), a river of Tasmania, Australia
- Wye River (Victoria), a minor river in Victoria, Australia
Settlements:
- Wye River, Victoria, a tourist village on the west coast of Victoria, Australia
Other:
- Wye River Memorandum, a political agreement between Israel and the Palestinian Authority concluded at the Aspen Institute Wye River Conference Centers in Maryland