Sarah Anne Tishkoff | |
|---|---|
| Born | December 26, 1965 United States |
| Alma mater | University of California, Berkeley (B.S.) Yale University (M.Phil., Ph.D.) |
| Spouse | Evan Leach |
| Awards |
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| Scientific career | |
| Fields | Population Genetics Epigenetics Genomics |
| Institutions | |
| Thesis | Patterns of nuclear haplotype frequency variation and linkage disequilibrium in a global sample of human populations (1996) |
| Doctoral advisor | Kenneth Kidd |
| Website | www |
Sarah Anne Tishkoff (born December 26, 1965) is an American geneticist and the David and Lyn Silfen Professor in the Department of Genetics and Biology at the University of Pennsylvania.[1] She also serves as a director for the American Society of Human Genetics and is an associate editor at PLOS Genetics, G3 (Genes, Genomes, and Genetics), and Genome Research. She is also a member of the scientific advisory board at the David and Lucile Packard Foundation.[2]
Tishkoff has been a leading figure in using genetics to advance understanding of modern human diversity. In particular she has made significant contributions to research on human genetic variation in African populations. In 1996, she and colleagues published the first paper to support the Out-of-Africa hypothesis using the nuclear genome, illustrating the extent of diversity among African populations.[3] In 2001, Tishkoff and colleagues were some of the first to show the genomic signature of natural selection in human populations.[4]
Some of her most cited research is a study on genomic variation around the lactase gene, the first to show coevolution of a cultural and genetic trait. Tishkoff was able to link evolution of cattle domestication to lactase persistence.[5] Her more recent work includes the largest genomic study across ethnically diverse Africans, and the identification of novel genetic variants associated with skin color.[6][7]
Tishkoff is a recipient of a National Institutes of Health Director's Pioneer Award, a David and Lucile Packard Career Award, a Burroughs/Wellcome Fund Career Award, and a Penn Integrates Knowledge (PIK) endowed chair.[1] She was elected to the National Academy of Sciences in 2017.[8]
- ^ a b "Tishkoff Lab / Sarah Tishkoff, Ph.D." www.med.upenn.edu. Retrieved 2018-11-06.
- ^ Tishkoff, Sarah A. "Curriculum Vitae" (PDF). Retrieved 5 November 2018.
- ^ Tishkoff, S. A.; Dietzsch, E.; Speed, W.; Pakstis, A. J.; Kidd, J. R.; Cheung, K.; Bonné-Tamir, B.; Santachiara-Benerecetti, A. S.; Moral, P. (1996-03-08). "Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins". Science. 271 (5254): 1380–1387. Bibcode:1996Sci...271.1380T. doi:10.1126/science.271.5254.1380. ISSN 0036-8075. PMID 8596909. S2CID 4266475.
- ^ Cite error: The named reference
:5was invoked but never defined (see the help page). - ^ Tishkoff, Sarah A.; Reed, Floyd A.; Ranciaro, Alessia; Voight, Benjamin F.; Babbitt, Courtney C.; Silverman, Jesse S.; Powell, Kweli; Mortensen, Holly M.; Hirbo, Jibril B. (January 2007). "Convergent adaptation of human lactase persistence in Africa and Europe". Nature Genetics. 39 (1): 31–40. doi:10.1038/ng1946. ISSN 1061-4036. PMC 2672153. PMID 17159977.
- ^ Tishkoff, Sarah A.; Reed, Floyd A.; Friedlaender, Françoise R.; Ehret, Christopher; Ranciaro, Alessia; Froment, Alain; Hirbo, Jibril B.; Awomoyi, Agnes A.; Bodo, Jean-Marie (2009-05-22). "The Genetic Structure and History of Africans and African Americans". Science. 324 (5930): 1035–1044. Bibcode:2009Sci...324.1035T. doi:10.1126/science.1172257. ISSN 0036-8075. PMC 2947357. PMID 19407144.
- ^ Crawford, Nicholas G.; Kelly, Derek E.; Hansen, Matthew E. B.; Beltrame, Marcia H.; Fan, Shaohua; Bowman, Shanna L.; Jewett, Ethan; Ranciaro, Alessia; Thompson, Simon (2017-10-12). "Loci associated with skin pigmentation identified in African populations". Science. 358 (6365): eaan8433. doi:10.1126/science.aan8433. ISSN 0036-8075. PMC 5759959. PMID 29025994.
- ^ "National Academy of Sciences Elects Four Penn Professors | Penn Today". Penn Today. 5 May 2017. Retrieved 2018-11-06.