Sex hormone

Sex hormone
Drug class
Estradiol, an important estrogen sex hormone in both women and men
Class identifiers
SynonymsSex steroid; Gonadal steroid
UseVarious
Biological targetSex hormone receptors
Chemical classSteroidal; Nonsteroidal
Legal status
In Wikidata

Sex hormones, also known as sex steroids, gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate steroid hormone receptors.[1] The sex hormones include the androgens, estrogens, and progestogens. Their effects are mediated by slow genomic mechanisms through nuclear receptors as well as by fast nongenomic mechanisms through membrane-associated receptors and signaling cascades.[2] The polypeptide hormones luteinizing hormone, follicle-stimulating hormone and gonadotropin-releasing hormone – each associated with the gonadotropin axis – are usually not regarded as sex hormones, although they play major sex-related roles.

  1. ^ Guerriero, G (April 2009). "Vertebrate sex steroid receptors: evolution, ligands, and neurodistribution". Annals of the New York Academy of Sciences. 1163 (1): 154–68. Bibcode:2009NYASA1163..154G. doi:10.1111/j.1749-6632.2009.04460.x. PMID 19456336. S2CID 5790990.
  2. ^ Thakur, MK; Paramanik, V (2009). "Role of steroid hormone coregulators in health and disease". Hormone Research. 71 (4): 194–200. doi:10.1159/000201107. PMID 19258710.

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