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Subthreshold membrane potential oscillations

Figure 1.

Subthreshold membrane potential oscillations are membrane oscillations that do not directly trigger an action potential since they do not reach the necessary threshold for firing. However, they may facilitate sensory signal processing.

Neurons produce action potentials when their membrane potential increases past a critical threshold. In order for neurons to reach threshold for action potential to fire, enough sodium (Na+) ions must enter the cell through voltage gated sodium channels through membrane and depolarize the cell.[1] The threshold is reached to overcome the electrochemical equilibrium within a neuron, where there is a balance between potassium ions (K+) moving down their concentration gradient (inside the cell to outside), and the electrical gradient that prevents K+ from moving down its own gradient.[2] Once the threshold value is reached, an action potential is produced, causing a rapid increase of Na+ enters the cell with more Na+ channels along the membrane opening, resulting in a rapid depolarization of the cell.[1] Once the cell has been depolarized, voltage-gated sodium channels close, causing potassium channels to open; K+ ions then proceed to move against their concentration gradient out of the cell.[3]

However, if the voltage is below the threshold, the neuron does not fire, but the membrane potential still fluctuates due to postsynaptic potentials and intrinsic electrical properties of neurons. Therefore, these subthreshold membrane potential oscillations do not trigger action potentials, since the firing of an action potential is an "all-or-nothing" response, and these oscillations do not allow for the depolarization of the neuron to reach the threshold needed, which is typically around -55 mV;[4] an "all-or-nothing" response refers to the ability of a neuron to fire an action potential only after reaching the exact threshold.[3] For example, figure 1 depicts the localized nature and the graded potential nature of these subthreshold membrane potential oscillations, also giving a visual representation of their placement on an action potential graph, comparing subthreshold oscillations versus a fire above the threshold. In some types of neurons, the membrane potential can oscillate at specific frequencies. These oscillations can produce firing by joining with depolarizations.[5] Although subthreshold oscillations do not directly result in neuronal firing, they may facilitate synchronous activity of neighboring neurons. It may also facilitate computation, particularly processing of sensory signals.[5] All in all, although the subthreshold membrane potential oscillations do not produce action potentials by themselves, through summation, they are able to still impact action potential outcomes.

  1. ^ a b Barnett, Mark W.; Larkman, Philip M. (2007-06-01). "The action potential". Practical Neurology. 7 (3): 192–197. ISSN 1474-7758. PMID 17515599.
  2. ^ Neuroscience. Purves, Dale, 1938- (5th ed.). Sunderland, Mass.: Sinauer Associates. 2012. ISBN 9780878936953. OCLC 754389847.{{cite book}}: CS1 maint: others (link)
  3. ^ a b Hopfield, J. J. (6 July 1995). "Pattern recognition computation using action potential timing for stimulus representation". Nature. 376 (6535): 33–36. Bibcode:1995Natur.376...33H. doi:10.1038/376033a0. ISSN 0028-0836. PMID 7596429. S2CID 4324368.
  4. ^ Bean, Bruce P. (2007). "The action potential in mammalian central neurons". Nature Reviews Neuroscience. 8 (6): 451–465. doi:10.1038/nrn2148. PMID 17514198. S2CID 205503852.
  5. ^ a b Lampl, I.; Yarom, Y. (1993-11-01). "Subthreshold oscillations of the membrane potential: a functional synchronizing and timing device". Journal of Neurophysiology. 70 (5): 2181–2186. doi:10.1152/jn.1993.70.5.2181. ISSN 0022-3077. PMID 8294979.

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